#01Nov 10, 2026
cs.CV
Continuous 3D Spatial Transcriptomics Reconstruction via Histology-Informed Implicit Neural Representations
Kaito Shiku, Ryoma Bise, Ahtisham Fazeel Abbasi and 4 more
Three-dimensional spatial transcriptomics (3D ST) enables the analysis of gene-expression patterns across tissue depths. However, 3D ST measurements are acquired from discrete 2D tissue sections, which are often sparsely sampled due to high acquisition costs. To address this limitation, we propose a histology-informed multi-task implicit neural representation (HIM-INR) for continuous 3D gene-expression reconstruction from sparse ST observations. HIM-INR jointly reconstructs gene-expression profiles and histological representations using an INR with a shared backbone, leveraging densely sampled histological images as auxiliary spatial supervision. Once trained, HIM-INR predicts gene expression at arbitrary 3D coordinates without requiring histological images. Experiments on two 3D ST datasets demonstrate improved reconstruction over existing methods, particularly as the number of missing ST sections increases.
#02Nov 10, 2026
cs.CV
AutoThreshold: Joint Confusion-Profile Learning for Adaptive Mask Binarization
Shaokai Wu, Xunchu Zhou, Pinzhi Wang and 5 more
A single validation-tuned threshold can become brittle when dense-score distributions shift. We introduce AutoThreshold, a post-hoc policy that predicts the joint mass of positive and negative pixels over score bins. This target directly parameterizes threshold-indexed confusion counts, avoiding products of independently estimated prevalence and class-conditional rates. Softmax normalization and cumulative decoding yield coherent, monotone confusion profiles; a plug-in decoder then selects a threshold for any $F_β$ objective without retraining the head. Across three independently trained Kvasir pipelines transferred to four polyp datasets, Joint exceeds continuous Otsu by $0.0080 \pm 0.0046$ external macro Dice, with positive gains in 3/3 runs. On the reference pipeline, three head seeds achieve $0.6324 \pm 0.0027$, 0.0085 above Otsu; direct-utility Ridge achieves 0.6342, with the paired difference interval spanning zero. The same Joint checkpoints outperform Otsu for $F_{0.5}$, Dice, and $F_2$. On developmental KITTI Road leave-one-corruption-family-out evaluation, Joint improves over scalar regression by 0.0082 [0.0064, 0.0101], while direct utility is 0.0022 higher. These results establish joint confusion prediction as a useful, metric-retargetable inductive bias, without claiming Bayes-optimal $F_β$ decisions.
#03Nov 10, 2026
cs.CV
Measuring Robustness and Efficiency in a Connectome-Constrained Fly Visual System Model: Linking an Adversarial and a Perceptual Illusion
Alexandre Garcia-Duran, Alejandro Rodriguez-Garcia, Manuel Molano-Mazón and 3 more
Biological visual systems compute reliably under tight metabolic and wiring constraints, whereas artificial vision systems consume far more energy and can be sensitive to adversarial perturbations. Whether networks with brain-like wiring are more robust at lower computational cost is unclear. We address this by benchmarking a task-optimized, continuous-time recurrent neural network of the fly visual system constrained by its synaptic connectome (FlyNet) against artificial neural networks. We compare it against CNNs, RAFT, and continuous-time recurrent neural networks without detailed connectome constraints (sCTRNN, CTRNN) on a collision-detection task within a differentiable 3D rendering pipeline. FlyNet is adversarially vulnerable but, relative to its compute, more robust to common video corruptions than RAFT, while using up to five orders of magnitude fewer FLOPs. The CTRNNs remain more robust than FlyNet across almost all tested perturbations, suggesting that connectome constraints benefit efficiency, through their low edge count, over robustness. Recurrence improves robustness to white-box attacks in RAFT and temporal context improves robustness to common corruptions. FlyNet's position and velocity representations degrade under adversarial textures but recover under counterfactual textures that restore correct classification while staying equally far from training, ruling out unfamiliar textures as the cause of failure. The reverse-phi illusion similarly disrupts these representations and inverts the same low-level motion statistic as the adversarial textures. Optimizing this input statistic alone, without access to the network, suffices to induce classification failure, attributing both perturbations to the same circuit vulnerability. Connectome-constrained models can thus surface adversarial failure mechanisms as testable hypotheses about biological perceptual vulnerabilities.
#04Nov 10, 2026
cs.RO
ForeseeDrive: Future-Token Conditioning for Anticipatory Generative Driving
Shaokai Wu, Xunchu Zhou, Pinzhi Wang and 8 more
Generative driving planners can represent diverse ego futures, but a downstream scorer can choose only among sampled candidates; it cannot recover an absent maneuver. We present ForeseeDrive, which turns future scene evolution into a deployable interface for shaping candidate generation. Rather than reconstructing dense future states or scoring a fixed menu, ForeseeDrive derives query-indexed tokens from logged actor motion, occupancy evolution, route interactions, and TTC margins, and predicts the same token space from present context at deployment. The tokens condition trajectory geometry before candidates materialize. A zero-token-gated residual path and candidate-preservation loss limit unnecessary drift, while a TTC-margin guard targets brittle safe-to-unsafe boundary crossings. Under their respective benchmark protocols, ForeseeDrive reaches 89.2 PDMS on NAVSIM navtest, 0.41\,m average L2 and 0.05\% collision rate on nuScenes validation, and a 76.50 driving score on Bench2Drive. Controlled DiffusionDrive/NAVSIM diagnostics show an exact zero-token no-op, a small aligned-over-shuffled selected-PDM advantage under preservation, mixed oracle-best quality, and localized TTC-boundary failures. Together, the benchmark results and bounded mechanism tests support future-conditioned generation as a practical interface for anticipation. Code is included in the supplementary materials.
#05Nov 10, 2026
cs.RO
Elastic-WAM: Adaptive Spatiotemporal Imagination for Efficient Robot Control
Haitian Li, Tianfu Li, Xuxi Zhao and 8 more
World-Action Models improve robot control by predicting future visual dynamics, but iterative video denoising incurs substantial inference overhead. Recent approaches reduce this cost through partial future denoising, yet typically rely on fixed refinement budgets. Our empirical observations reveal that preferred refinement depths vary across tasks and states, while different future regions exhibit varying relevance to action generation. Motivated by these findings, we propose Elastic-WAM, which adaptively allocates world refinement computation across temporal denoising time and spatial future space. A unified spatiotemporal refinement demand field governs when to stop world refinement, how far to advance each denoising step, and which regions to refresh. We parameterize this field with a shared temporal basis and spatial amplitudes, and learn it through a three-stage action-grounded supervised procedure. At inference, the learned field guides recurrent sparse world refinement to improve task success while reducing inference overhead. Evaluations across diverse simulation benchmarks and real-world long-horizon manipulation demonstrate state-of-the-art control performance with reduced inference latency.