#01Jul 20, 2026
cs.LG
Differentiable Logic Gate Networks for Low-Latency EEG Classification on Edge Devices
Shyamal Y. Dharia, Stephen D. Smith, Camilo E. Valderrama
Real-time EEG classification on edge devices is bottlenecked by the floating-point arithmetic of conventional neural networks. We investigated Differentiable Logic Gate Networks (Diff-Logic) as a hardware-native alternative that compiles models into pure Boolean circuits executable via bitwise CPU operations. Through rigorous iso-parameter experiments across four EEG datasets spanning two classification tasks, binary dementia detection and 3-class emotion recognition, we compared Diff-Logic against matched-capacity Multi-Layer Perceptron (MLP) and Binarized Neural Network (BNN) baselines at four complexity tiers (50k-500k parameters). On dementia screening, Diff-Logic achieved 80.2% Macro F1, outperforming the MLP baseline by 6.8%. On emotion recognition, the MLP retained a moderate performance advantage but incurred a 2.3$\times$ higher latency and 14$\times$ larger model size when deployed on a power-constrained (7W) Nvidia Jetson Orin Nano CPU (Single-core). Critically, Diff-Logic inference time remained nearly constant across a 10$\times$ increase in model scale, achieving a peak speedup of 2.9$\times$ over MLPs at the largest complexity tier. Our results establish logic-based neural architectures as a practical paradigm for resource-constrained brain-computer interfaces, achieving competitive or superior performance while natively satisfying the latency and memory constraints of portable edge deployment. Code is available on GitHub: https://github.com/Shyamal-Dharia/eeg-difflogic
#02Jul 20, 2026
cs.LG
SGN: A Similarity-based Generative Network for Data Generation under Distribution Shift
Jiaqi Zhu, Xincheng Chen, Yuncheng Wu and 2 more
Generative models trained on a source domain often produce samples that are poorly aligned with shifted target domains, limiting their effectiveness for target-domain data augmentation. Although target-specific adaptation can reduce this mismatch, it typically requires additional optimization and domain-specific parameters. We propose a Similarity-based Generative Network (SGN), a reusable framework that is trained once on labeled source data and applied to new target domains without parameter updates. SGN learns a latent space structured by label-induced pairwise similarities while preserving reconstructive information through an encoder-decoder architecture. At generation time, a small labeled representative set from the target domain is encoded and combined in the learned latent space, allowing the generated samples to inherit target-specific characteristics while maintaining class consistency. We further analyze the realizability and dimensionality requirements of the proposed similarity structure. Experiments on image and tabular datasets demonstrate the effectiveness of SGN for target-guided data augmentation under source-to-target distribution shifts.
#03Jul 20, 2026
cs.CV
GigaPath-Flash and GigaTIME-Flash: Efficient Pathology Foundation Models for Whole-Slide and Tumor Microenvironment Analysis
Naoto Usuyama, Jeya Maria Jose Valanarasu, Sicong Yao and 24 more
Foundation models have emerged as a driving force in computational pathology, with the potential to transform cancer diagnosis, prognosis, and treatment selection by learning transferable representations from large-scale histopathology data. A growing landscape of pathology foundation models now spans diverse data sources, architectures, and downstream applications. However, most pretrained models operate only at the image-tile level, use restrictive licenses, and remain computationally expensive, limiting large-scale slide-level clinical and research use. Here, we introduce GigaPath-Flash and GigaTIME-Flash, efficient models for whole-slide pathology AI and spatial proteomics prediction. GigaPath-Flash combines a 22M-parameter ViT-S tile encoder with a 21M-parameter LongNet slide encoder, both pretrained on large-scale real-world histopathology data. Its compact tile encoder is distilled from the billion-parameter GigaPath (ViT-g) teacher and shared by both models. GigaPath-Flash retains 97% of GigaPath's average slide-level performance with 50x less compute. GigaTIME-Flash extends this backbone to predict the tumor immune microenvironment directly from routine H&E images. It surpasses the original CNN-based GigaTIME in prediction quality while running 6x faster and using 8x less GPU memory. Together with GigaPath and GigaTIME, these models form an open-weight, Apache-2.0-licensed family pretrained on large-scale real-world clinical data. By releasing all models and weights, we provide accessible building blocks for computational pathology, immuno-oncology, and precision health.
#04Jul 20, 2026
cs.CL
PPL-Factory: Task-Aware and Budget-Aware Data Selection from Language Modeling to Reasoning
Hang Zhang, Warren J. Gross
Not all training samples contribute equally to large language model fine-tuning. Selecting informative training samples can reduce the computational cost while preserving downstream performance. Many existing data selection methods rely on indirect heuristics, such as data quality, diversity or reasoning trace length. However, the effectiveness of these fixed criteria is task-dependent and difficult to generalize across diverse downstream tasks. Perplexity-based data selection provides a simple and model-aware solution to estimate the sample difficulty, but existing approaches typically score the entire training sequence and ignore the difference in learning objectives of language modeling and reasoning tasks. In this paper, we propose PPL-Factory, a simple and interpretable data selection framework that combines task-aware perplexity-based scores and data budget-aware selection criteria. Experiments on GSM8K demonstrate that PPL-Factory outperforms other state-of-the-art data selection methods using only $1\%$ of the training set. With $10\%$ of the data, PPL-Factory exceeds full-data fine-tuning accuracy by 0.9 on GSM8K and 4.8 on MATH. Overall, our results demonstrate that task-aware and budget-aware perplexity-based selection provides an effective and applicable approach for efficient fine-tuning.
#05Jul 20, 2026
cs.LG
Do Language Models Dream of Binding Molecules? Benchmarking LLMs under Spatial Constraints
Thomas MacDougall, Maksim Kuznetsov, Roman Schutski and 5 more
Structure-based drug design (SBDD) leverages the 3D structure of protein targets, often complemented by other spatial constraints, to generate candidate binding molecules. While diffusion models have dominated as a leading paradigm for high-quality 3D molecule generation, LLM-based methods are rapidly emerging in molecular design and have shown competitive performance in pocket-conditioned molecular generation. However, their ability to reason about physics and 3D spatial environments is largely underexplored. In this work, we systematically analyze whether current general-purpose LLMs are capable of navigating complex 3D constraints compared to established baselines such as specialized diffusion models. We consider 3D ligand generation conditioned on protein pockets together with ligand- and interaction-derived spatial constraints, including anchor fragments, pharmacophore points, and mandatory pocket-ligand interactions. To enable this evaluation, we introduce 3D-Fit - a token-efficient benchmarking strategy for assessing LLM performance on multi-conditioned spatial molecule generation. Our findings reveal a clear pattern in LLM spatial capabilities: while they still lag behind state-of-the-art approaches, they are promising and can handle multiple spatial constraints simultaneously, enabling scaling to heterogeneous setups.