#01Nov 9, 2026
cs.LG
HyPLM Technical Report
Haowei Lin, Cai Zhou, Xiangxin Zhou
Protein language models (PLMs) are standard tools for variant-effect prediction, protein annotation and design, but the compute needed to train and serve them keeps growing. We present HyPLM-Flash, an efficient and open PLM trained by Hyra 2.0, the research agent developed by our team. HyPLM-Flash is a 650-million-parameter masked language model trained on 726 billion tokens, 0.73 times the data of ESM-2 650M and a fifth to an eighth of the data of E1-600M and ESM C 600M. It runs on an inference engine with fused kernels and INT8 matrix multiplication, embedding about 130,000 residues per second on a single NVIDIA H20 GPU, 1.9 to 2.7 times faster than other 600M-class encoders. In a matched evaluation against 28 public checkpoints on 32 tasks, HyPLM-Flash reaches a ProteinGym zero-shot Spearman correlation of 0.409, statistically tied with ESM-2 650M, ESM C 600M and E1-600M, and the highest organismal-fitness score among self-supervised single-sequence models. It gives the best long-range contact precision of all models evaluated, including ESM-2 15B and ESM C 6B, and a lower masked-residue loss than ESM-2 650M, ESM C 600M and E1-600M on held-out sequences and on recently released PDB chains. Matching state-of-the-art accuracy at a fraction of the training and inference cost, HyPLM-Flash sets a new Pareto frontier for protein language models. We have released the model weights and the inference engine at https://github.com/Tencent-Hunyuan/hyra-results/tree/main.
#02Nov 9, 2026
stat.ME
Conformal Prediction for Multi-Step Forecasting: Conditional Coverage and Sharp Score Calibration Rates
Siyuan He, Yuhong Yang
Uncertainty quantification in prediction is a central problem in statistics and machine learning. Conformal prediction provides a flexible approach to constructing prediction sets with valid marginal coverage under exchangeability. In this paper, we investigate conformal prediction for both one-step and multi-step forecasting from a single stationary time series, addressing temporal dependence and the additional challenges of joint prediction across multiple horizons. We propose a kernel-based framework, called Time series Residual Analysis for Calibration with Kernels (TRACK), for estimating conditional quantiles of residual scores and constructing prediction sets from rolling-window forecasters. The framework accommodates heterogeneous uncertainty across horizons and accounts for dependence induced by rolling estimation, while allowing predictor memory and forecast horizons to grow with the sample size. Our finite-sample bounds quantify how temporal dependence and overlapping score windows affect calibration and coverage. We further derive bounds for conditional quantile estimation and pointwise conditional coverage discrepancy. The guarantees extend to more general predictors that admit an accurate rolling-window approximation. We also derive matching minimax bounds over classes of known score maps, clarifying how overlapping score windows affect calibration accuracy. Experimental results from simulations and applications to wind energy generation and bike sharing demand show that our methods improve regional conditional coverage while maintaining competitive interval widths.
#03Nov 9, 2026
cs.SD
MUTE: Multi-Level Alignment Uncoupling Against Talking-Head Exploitation for Voice Protection
Donghyun Kim, Jin Hong, Seungmin Kim and 3 more
Talking-head generation models, which synthesize realistic facial animations from audio, are increasingly vulnerable to misuse in multimodal deepfake scenarios. Protecting such systems remains challenging, as talking-head models fundamentally rely on precise audio-visual alignment, while effective audio protection methods remain largely underexplored. In this work, we propose MUTE, an audio protection framework that uncouples the underlying audio-visual alignment through a multi-level strategy. Specifically, MUTE combines (1) Alignment-level Disruption, which directly perturbs cross-modal attention to disrupt structural alignment, and (2) Representation-level Degradation, which perturbs temporal audio embeddings to degrade their representations. To improve robustness, perturbations are constrained in the STFT domain to high-energy regions, making them resistant to post-processing, denoising, and adaptive attacks. An optional speaker-level objective further mitigates potential bypass via TTS-based resynthesis. Extensive experiments demonstrate that MUTE consistently degrades lip synchronization across both white-box and black-box talking-head models while preserving perceptual audio quality. The proposed method remains effective under real-world transformations and can be combined with image-based approaches to provide stronger multimodal protection. The source code and project page are available at https://github.com/jindl465/MUTE.
#04Nov 9, 2026
cs.LG
Constrained Variational Policy Optimization for Hybrid Action Spaces
Shuchang Yan
Constrained reinforcement learning in hybrid action spaces must coordinate discrete modes and mode-conditioned continuous controls under long-horizon cost constraints. Existing constrained hybrid-action methods typically optimize factorized policies directly in parameter space, whereas Constrained Variational Policy Optimization (CVPO) separates nonparametric improvement from parametric projection in its original continuous-action formulation. We introduce Hybrid Constrained Variational Policy Optimization (H-CVPO), extending this variational framework to hybrid action spaces. Under boundedness and strict feasibility, its constrained E-step has zero duality gap and, when the dual optimum is attained at positive temperature, yields a closed-form joint target distribution over hybrid actions through exponential reward-cost reweighting. Using the exact hybrid KL decomposition, we formulate a factorized M-step that fits both policy components to this target under separate discrete and conditional-continuous trust regions. For exact E/M updates, we prove fixed-reference surrogate improvement and conditional reward-cost bounds with a sufficient feasibility-margin condition. For approximate updates, we establish the existence of a dual minimizer under continuity on a compact domain and use residual-based admissibility to determine whether to project the target. Ablations identify cost-aware reweighting as an important contributor to constraint control. Extensive experiments in simulated hybrid-control environments show that H-CVPO achieves favorable reward-cost trade-offs compared with hybrid-action baselines.
#05Nov 9, 2026
cs.LG
LBSNet: Lightweight Brain State Modeling via Learnable Spectral Prototypes for EEG-Based Fatigue Detection
Kun Jia, Zhenyu Cao, Hanlin Yu and 5 more
EEG-based fatigue detection requires modeling spectral information across bands and its temporal variation. Recent methods combine multi-band modeling with adaptive temporal processing, yet how spectral structure across bands should influence the contribution of each temporal interval remains insufficiently explored. We propose LBSNet, a lightweight network that uses prototype-based brain-state modeling to link local spectral structure with temporal aggregation. LBSNet extracts compact multi-band features through band-specific temporal convolution, shared spatial projections, and cross-band recalibration. Within each window, relative spectral activity is encoded as a normalized descriptor and softly matched to learnable spectral prototypes. Prototype assignments and learned prototype importance jointly determine temporal weights for power aggregation, allowing the spectral pattern of each window to guide its contribution to the prediction. Subject-independent experiments on SEED-VIG and SADT show that LBSNet outperforms seven baselines while maintaining low computational cost. Ablation and visualization analyses support prototype-guided temporal weighting, while the learned prototypes reveal a gradual redistribution of relative cross-band spectral states with increasing fatigue. The code is publicly available at https://github.com/zy0929/LBSNet.