#01Nov 10, 2026
cs.CV
Measuring Robustness and Efficiency in a Connectome-Constrained Fly Visual System Model: Linking an Adversarial and a Perceptual Illusion
Alexandre Garcia-Duran, Alejandro Rodriguez-Garcia, Manuel Molano-Mazón and 3 more
Biological visual systems compute reliably under tight metabolic and wiring constraints, whereas artificial vision systems consume far more energy and can be sensitive to adversarial perturbations. Whether networks with brain-like wiring are more robust at lower computational cost is unclear. We address this by benchmarking a task-optimized, continuous-time recurrent neural network of the fly visual system constrained by its synaptic connectome (FlyNet) against artificial neural networks. We compare it against CNNs, RAFT, and continuous-time recurrent neural networks without detailed connectome constraints (sCTRNN, CTRNN) on a collision-detection task within a differentiable 3D rendering pipeline. FlyNet is adversarially vulnerable but, relative to its compute, more robust to common video corruptions than RAFT, while using up to five orders of magnitude fewer FLOPs. The CTRNNs remain more robust than FlyNet across almost all tested perturbations, suggesting that connectome constraints benefit efficiency, through their low edge count, over robustness. Recurrence improves robustness to white-box attacks in RAFT and temporal context improves robustness to common corruptions. FlyNet's position and velocity representations degrade under adversarial textures but recover under counterfactual textures that restore correct classification while staying equally far from training, ruling out unfamiliar textures as the cause of failure. The reverse-phi illusion similarly disrupts these representations and inverts the same low-level motion statistic as the adversarial textures. Optimizing this input statistic alone, without access to the network, suffices to induce classification failure, attributing both perturbations to the same circuit vulnerability. Connectome-constrained models can thus surface adversarial failure mechanisms as testable hypotheses about biological perceptual vulnerabilities.
#02Nov 10, 2026
cs.AI
Contrastive Discovery: Open-Ended Scientific Discovery over Competing Explanations
Ziang Liu, James J. Kim, Yijia Dai and 1 more
LLM agents are increasingly used for open-ended, data-driven scientific discovery, yet most of them evaluate hypotheses pointwise, testing an empirical claim $h$ only against its complement $\neg h$. When evidence rejects $h$, the agent learns that one explanation is unlikely but not which alternative the evidence supports. To recover that alternative, we introduce Contrastive Discovery, which replaces the single hypothesis with a contrast set, a scientific question paired with mutually exclusive and collectively exhaustive competing explanations. Each experiment is scored by how its evidence redistributes belief across the set, and the question is resolved when belief concentrates on one explanation. Because contrast sets change only the unit an agent proposes and scores, an existing agent can use them to re-evaluate evidence it has already collected or to guide its search. Across six domains, $89\%$ of the pointwise candidates with the largest belief shifts are rejections. On the same evidence, contrast sets resolve $73\%$ of these candidates to a specific alternative. When contrast sets guide search, the agent resolves $67\%$ more questions than pointwise surprisal under the same experiment budget. In a blinded study, $38$ human experts chose the same explanation on $78\%$ of resolved questions and on $82\%$ of questions where the pointwise agent rejected its hypothesis and stopped. Together, these results support explicit competing explanations as a way for discovery agents to resolve more scientific questions from the same evidence and validation budget.
#03Nov 10, 2026
cs.LG
TorchCurves: Differentiable Parametric Curves
Alex Shtoff
We present TorchCurves, a PyTorch library that treats vector-valued parametric curves as learnable primitives. Its central operation maps batches of scalar inputs to points on curves represented in B-spline or Legendre polynomial bases, with differentiation through both inputs and coefficients. Curve coefficients can be optimized jointly with the surrounding model or produced by another network. The library provides trainable modules, reusable basis modules, and a functional interface, supporting applications ranging from continuous feature embeddings to Kolmogorov-Arnold networks and functional regression. Its implementation combines classical evaluation algorithms with vectorized PyTorch operations, emphasizing readability and maintainability without custom hardware kernels. Timing experiments compare curve evaluation against NumPy and SciPy and KAN training against EfficientKAN across a range of problem sizes. The results illustrate where this generality remains computationally practical and where overhead is substantial. Library is available on GitHub at https://github.com/alexshtf/torchcurves.
#04Nov 10, 2026
cs.CV
BoviShift: A Six-Year Multi-Attribute Audit of Visual Cattle Phenotyping Across Animals and Time
Mobasshir Bhuiya Shagor, Nilambar Halder Tonmoy, Md Saef Ullah Miah
Computer vision offers a scalable, non-contact means of estimating livestock traits, but correlated images and video frames make reliable evaluation difficult. Image-random splitting can place views of the same animal in both training and test sets, while deployment further requires transfer to animals captured in future years. We introduce BoviShift, a corpus reconstructed from six consecutive annual cohorts of an operational cattle marketplace collected from 2021 to 2026. It contains 2{,}657 cattle, 10{,}610 still images, and 2{,}566 walk-around videos across nine recorded breed categories. We evaluate three splitting strategies through four configurations: image-random and pooled cattle-disjoint splits over the same development cohorts, followed by separate future-2025 and locked future-2026 evaluations. Using a fixed ResNet-50 multi-task baseline, we assess weight, age, height, breed, and coat color. Differences between image-random and cattle-disjoint splitting are task-dependent rather than a universal leakage penalty. Future-cohort behavior is also attribute- and cohort-specific: breed declines relative to pooled evaluation; mean weight and age performance fails to beat constant baselines in 2025; height remains above baseline; and color transfers well to 2025 but degrades in 2026. Multi-task training improves all five point estimates in a single-seed ablation, still-view aggregation helps selectively, and zero-shot video-frame aggregation exposes a still-to-video domain gap. To our knowledge, BoviShift is the longest-spanning cattle-vision resource combining consecutive annual cohorts with physical and visual attributes.
#05Nov 10, 2026
cs.LG
Pyrite: Building and Benchmarking Protein-Ligand Pose Ranking Agents
Megha Srivastava, Michael H. Lim, Allison M. Keys and 2 more
Predicting how a ligand binds to its target is central to small-molecule drug discovery. Modern cofolding models can generate diverse candidate poses, but reliably ranking these candidates remains challenging. We introduce Pyrite, a pairwise pose-ranking benchmark comprising 1,500 pose pairs across diverse protein-ligand complexes. Expert chemists equipped with 3D visualization tools and physics-based scores perform near chance, highlighting the difficulty of interpreting available chemical signals. To investigate automated ranking, we introduce PyriteRep, a structured representation of molecular geometry, protein-ligand interactions, and physicochemical scores, and develop two LLM-based agents: PyriteReasoner, which directly compares poses through text-based reasoning, and PyriteFeaturizer, which generates executable code to construct features for logistic regression, optionally incorporating features derived from LLM subcalls. These agents achieve up to 67% and 74% accuracy, respectively, exceeding observed expert performance. LLM-guided feature discovery generally outperforms direct reasoning, while Group Relative Policy Optimization (GRPO) improves open-weight models, enabling them to match or surpass closed-source frontier models in our evaluations. These results establish Pyrite as a challenging test of pose-ranking ability and highlight LLM-guided feature discovery as a promising approach to interpret and combine the outputs of computational chemistry tools.