#01Sep 4, 2026
cs.CV
Conserved Immune Topology Improves Pathology Foundation Model Generalization for Cross-Cancer MSI-H Prediction
Dasari Naga Raju
Pathology foundation models integrated with multiple instance learning achieve competitive accuracy within single-cancer cohorts, yet cross-cancer generalization remains unresolved due to organ-specific histological and architectural differences. In this paper, we propose Conserved Immune Topology (CIT), a lightweight spatial representation for cross-cancer MSI-H prediction that augments foundation-model embeddings with biologically motivated immune descriptors. CIT uses unsupervised clustering to identify immune-associated tiles, then encodes tertiary lymphoid structures, peritumoral immune reactions, multi-scale tumor-infiltrating lymphocyte density, and immune-tumor mixing from frozen foundation-model embeddings and tile coordinates without requiring annotations or target-domain data. The proposed method was evaluated under cross-site and cross-cancer settings using CPTAC-COAD and TCGA-STAD cohorts, which introduce scanner variability, distribution shifts, and organ-specific architectural variations. Zero-shot cross-cancer transfer with CIT increased TransMIL AUC from 0.6627 to 0.7161, an absolute gain of 0.0534 (p=0.003), with consistent improvements across all three MIL aggregators. These results suggest that spatial immune topology provides potentially an organ-invariant representation for MSI-H prediction, supporting cross-cancer generalization of pathology foundation models.
#02Sep 4, 2026
eess.IV
Real-World Multi-Modal and Longitudinal Lung Cancer Dataset
Rita Cordeiro Mendes, Maria Rita Fonseca Verdelho, Carlos Santiago and 1 more
Multi-modal learning has demonstrated strong potential in medical applications by integrating heterogeneous data sources such as medical imaging, clinical records, and genomics to improve predictive performance and support clinical decision-making. However, advances in this area are often constrained by two key challenges: the limited availability of well-curated, ready-to-use datasets that accurately reflect real-world conditions, where medical data are frequently collected inconsistently and are often incomplete; and the inherent difficulty of integrating heterogeneous data modalities. In this work, we introduce a newly curated multi-center, multi-modal, and longitudinal dataset designed to support the evaluation of a wide range of learning pipelines under realistic conditions. The dataset comprises a total of 1,365 lung cancer patients and has three imaging modalities (whole-slide images, CT scans, and PET scans), structured clinical data, transcriptomic, and longitudinal follow-up and treatment information. For each imaging modality the dataset contains more than one instance. Moreover, the dataset exhibits substantial and non-uniform missingness across modalities, making it well-suited for studying robust multi-modal fusion strategies. We further provide both uni-modal and multi-modal benchmarks on the task of 12-month overall survival prediction, disease-specific survival, as well as longitudinal benchmark of hazard prediction under severe missing data. Our results show that, despite high levels of missingness, integrating complementary modalities consistently improves predictive performance over uni-modal approaches, highlighting the value of multi-modal fusion in realistic clinical settings. The dataset and benchmark code are available at https://github.com/ritacmendes/MMIST-LUNG.
#03Sep 4, 2026
cs.RO
What Matters, When? Diagnosing and Improving Conditional Visual Grounding in Visuomotor Imitation Policies
Vivek Chavan, Pengtao Xie, Yahuan Shi and 3 more
Visuomotor imitation policies can achieve high performance under in-distribution visual conditions yet fail when visually similar objects or receptacles are introduced. We study this behavior as a problem of conditional visual grounding: the visual target required for successful control changes with the manipulation phase and, in more complex tasks, with the observed task state. Using Action Chunking with Transformers (ACT), we systematically introduce distractor objects and receptacles with controlled color and shape similarity and localize failures to picking and placement. We find that distractor sensitivity is specific to both the type of visual similarity and the manipulation stage. Guided by this diagnosis, we evaluate distractor augmentation, phase-dependent attention regularization, and appearance-based visual prompting as complementary interventions for improving target selection while preserving spatial information required for control. These interventions substantially improve robustness in simulation and on a physical UR3e. We further examine the same failure pattern in a pretrained vision-language-action policy on a state-conditioned instrument-handling task, where the observed state of a medical instrument determines the correct destination. Together, the results show that visual distractors can cause incorrect object or destination selection even when the underlying manipulation skill remains intact, and that explicitly improving target selection can substantially recover performance across distinct visuomotor policy-learning regimes.
#04Sep 4, 2026
cs.CV
Lightweight Vision Transformer Compression for On-Device Plant Disease Detection in Resource-Constrained Agricultural Field Conditions
Mahadev Sunil Kumar, Bhavika Gondi, Desaisetty Venkata Satya Sai Swapnith and 6 more
Chilli (Capsicum annuum) is one of India's most economically significant crops, yet its productivity is persistently threatened by diseases that are difficult to identify without expert intervention. While Vision Transformers (ViTs) have achieved high classification accuracy, their large computational footprint makes deployment on resource constrained devices challenging. Existing compression approaches typically address pruning, quantization, and knowledge distillation in isolation, leaving the potential benefits and interactions of their combined application insufficiently explored. We propose a unified Vision Transformer compression framework that combines Hessian-Balanced Adaptive Block Pruning (H-BAC), guided by second-order sensitivity estimation, with quantization and attention-based knowledge distillation. To systematically identify the most effective configuration within each compression family, each technique is first evaluated independently through controlled ablation studies, after which the best-performing components are integrated into a sequential deployment pipeline tailored to real-world agricultural constraints. On a chilli 3-class village-split dataset with a genuine cross-village, cross-device out-of-distribution test split, the resulting compressed models match or exceed the 95.13% FP32 baseline's accuracy, alongside 74-98% model size reduction, and the fully integrated compression pipeline achieves a 54.5x size reduction (327.42 MB to 6.01 MB) at 95.13 +/- 2.32% accuracy across four tested configurations. A direct comparison further reveals that, on this dataset, a directly-trained student of the same final size, without pruning or distillation, reaches comparable accuracy of 94.87%, at the same 6.01 MB INT8 size, indicating where H-BAC and knowledge distillation are, and are not yet shown to be, worth their computational cost.
#05Sep 4, 2026
cs.CV
SMILE: Self-Explainable Multimodal Information Bottleneck for Medical Diagnosis
Yuqing Yang, Alexander Schmatz, Zhaozhao Ma and 3 more
Explainability is increasingly seen as a crucial requirement in AI-based medical diagnosis, particularly in safety-critical clinical decision-making. Most existing explainability methods in healthcare operate in a post-hoc manner and are predominantly designed for unimodal data, which limits their applicability in increasingly prevalent multimodal diagnostic settings. This paper addresses the problem of self-explainable multimodal diagnosis by formulating it within the information bottleneck (IB) framework. We propose a unified learning paradigm that jointly optimizes predictive performance and modality-specific explainability by identifying the most informative elements inside each modality that contribute to diagnostic decisions. To enable tractable and stable optimization, we employ a matrix-based Renyi's $α$-order entropy functional under the assumption of sufficiently expressive encoders. Extensive experiments on representative medical datasets spanning heterogeneous modalities demonstrate that the proposed method consistently achieves strong diagnostic performance, including an absolute accuracy improvement of 9.1 percentage points on the iCTCF dataset. Moreover, the learned explanations provide transparent and modality-aware insights into feature relevance, thereby improving both the explainability and generalization.