#01Sep 4, 2026
eess.IV
Real-World Multi-Modal and Longitudinal Lung Cancer Dataset
Rita Cordeiro Mendes, Maria Rita Fonseca Verdelho, Carlos Santiago and 1 more
Multi-modal learning has demonstrated strong potential in medical applications by integrating heterogeneous data sources such as medical imaging, clinical records, and genomics to improve predictive performance and support clinical decision-making. However, advances in this area are often constrained by two key challenges: the limited availability of well-curated, ready-to-use datasets that accurately reflect real-world conditions, where medical data are frequently collected inconsistently and are often incomplete; and the inherent difficulty of integrating heterogeneous data modalities. In this work, we introduce a newly curated multi-center, multi-modal, and longitudinal dataset designed to support the evaluation of a wide range of learning pipelines under realistic conditions. The dataset comprises a total of 1,365 lung cancer patients and has three imaging modalities (whole-slide images, CT scans, and PET scans), structured clinical data, transcriptomic, and longitudinal follow-up and treatment information. For each imaging modality the dataset contains more than one instance. Moreover, the dataset exhibits substantial and non-uniform missingness across modalities, making it well-suited for studying robust multi-modal fusion strategies. We further provide both uni-modal and multi-modal benchmarks on the task of 12-month overall survival prediction, disease-specific survival, as well as longitudinal benchmark of hazard prediction under severe missing data. Our results show that, despite high levels of missingness, integrating complementary modalities consistently improves predictive performance over uni-modal approaches, highlighting the value of multi-modal fusion in realistic clinical settings. The dataset and benchmark code are available at https://github.com/ritacmendes/MMIST-LUNG.
#02Sep 4, 2026
cs.CV
Learning Spatial-Spectral Refinement and Calibrating Complementary Observations for Hyperspectral Image Super-Resolution
Liqian Yang, Xingchi Chen, Xinfeng Gui and 2 more
Hyperspectral and multispectral image fusion (HMIF) aims to reconstruct a high-resolution hyperspectral image (HR-HSI) by combining the fine spatial details of a high-resolution multispectral image (HR-MSI) with the rich spectral information of a low-resolution hyperspectral image (LR-HSI). Recent advances in implicit neural representations (INRs) have enabled flexible coordinate-based modeling for HMIF; however, existing INR-based approaches may not fully capture fine-grained spatial structures and rich spectral dependencies. Moreover, the LR-HSI and HR-MSI are primarily incorporated through degradation-consistency constraints, leaving their complementary information underexploited. To address these limitations, we propose Two-Stage Reconstruction with Implicit Tensor Neural Representation (TSR-ITNR), a unified self-supervised framework integrating representation refinement and observation-guided calibration. In Stage 1, TSR-ITNR learns an implicit Tucker representation and refines its low-rank spatial coefficient tensor and spectral basis to better capture fine spatial structures and interband correlations. A fixed pretrained denoiser further provides a deep prior for the preliminary reconstruction. In Stage 2, parameter-free calibration derives complementary and noninterfering corrections from both observations to recover information insufficiently captured in Stage 1. Theoretical analysis establishes the geometry-preserving property of spectral refinement and the orthogonal complementarity of calibration. Extensive experiments on multiple benchmark datasets demonstrate strong quantitative, visual, and spectral reconstruction performance without ground-truth HR-HSI supervision. Beyond conventional reconstruction metrics, we further assess the effectiveness of TSR-ITNR using downstream semantic segmentation accuracy.
#03Sep 4, 2026
cs.CV
A Generalizable Feature Extractor for Alzheimer's-Related Brain MRI Tasks
Reza Rajabli, D. Louis Collins
When there is not enough labeled data to properly train deep learning models, transfer learning can help. We still do not fully understand how effective it is in neuroimaging, especially for Alzheimer's disease research. It is also not clear if these transferred models can work on new datasets without being retrained for each specific task. We evaluate whether a compact, supervised pretrained model can serve as a reusable foundation model for downstream neuroimaging tasks. We freeze the 7.18 million weights of a 3D CNN previously trained for brain-age prediction, and adapt it to each task using Low-Rank Adaptation (LoRA), requiring only ~1% additional trainable parameters. We evaluate generalizability in six experiments. Adapting the model to classify cognitively normal versus Dementia on ADNI gave an AUC of 0.964 on held-out folds (Experiment #1). Applying that adapted model unchanged to OASIS-3, with no retraining, gave an AUC of 0.871 (Experiment #2). Reusing its output logit together with age and a cognitive score distinguished stable from progressing MCI with an AUC of 0.828 (Experiment #3). Adapting the same backbone to predict amyloid positivity from structural MRI gave an AUC of 0.804 (Experiment #4). Finally, the same approach estimated ICV-normalized hippocampal and white matter hypointensity volumes directly from the T1w image, with R^2 of 0.80 and 0.91 respectively, tasks normally addressed with much larger U-Net networks (Experiments #5 and #6). A compact model supervised on brain age can therefore serve as a reusable backbone, adapting to each task with ~1% additional parameters and transferring to an unseen cohort without any training. Our findings suggest that a carefully trained brain age model can serve as an effective foundation model for Alzheimer's related tasks, even under strict data constraints.
#04Sep 4, 2026
cs.RO
RoboSPA: Can VLA Models Go Beyond Simple Scenes and Short-Horizon Tasks?
Zhenxuan Fan, Bo Zhang, Yutong Lin and 9 more
Vision-Language-Action (VLA) models have shown promising progress in language-conditioned robotic manipulation. However, existing datasets and benchmarks mainly evaluate task completion under predefined settings, offering limited insight into model reasoning under increasing spatial and procedural complexity. We introduce \textbf{RoboSPA} (\textbf{Robo}t \textbf{S}patial-\textbf{P}rocedural \textbf{A}ssessment), a large-scale robotic manipulation dataset and benchmark for diagnosing embodied reasoning in VLA models. \texttt{RoboSPA} focuses on two core dimensions, Fine-Grained Spatial Reasoning and Long-Horizon Procedural Planning, covering 10 task categories and 56 base tasks. Each task is instantiated across five difficulty levels, yielding 280 variants with increasing spatial ambiguity and procedural complexity. We collect 527K trajectories across multiple embodiments and diverse scenes. Beyond binary success rate, \texttt{RoboSPA} introduces diagnostic metrics for more detailed evaluation. Experiments on representative VLA models show that current systems still struggle with complex spatial relations, precise low-level execution, and memory-intensive planning. These results establish \texttt{RoboSPA} as a challenging diagnostic benchmark for developing more capable, reliable, and generalizable embodied agents. Our data and code are available at https://github.com/fanzhenxuan/RoboSPA.
#05Sep 4, 2026
cs.CV
Scalable Detection of Fossil Palynomorphs in Multifocal Digital Microscopy Images
Abbas Shaikh, Praise Mayor, Patrick Ainlay-Vazquez and 7 more
Palynomorphs (microscopic, organic-walled fossils such as pollen, spores, and dinoflagellates) are important high-resolution records of past climates and are critical to the study of ancient ecosystems. Existing methods rely on manual analysis of high-resolution, multifocal digital microscopy images, which is slow and time-consuming and requires researchers to compromise on the scale of their investigations. To the best of our knowledge, our work proposes the first ever scalable end-to-end pipeline for automated palynomorph detection in whole slide images that addresses this bottleneck through: (1) efficient methods for decomposing and compressing digitized multifocal microscope slide images into tractable 2-dimensional tiles for analysis; (2) benchmarking modern object detection models, including RF-DETR, for the detection of palynomorphs, achieving an AP@50 of 0.879; (3) an efficient algorithm for the synthesis of detection outputs across large-scale, high-resolution images; and (4) an I/O optimization resulting in faster inference time. Our methods drastically reduce the time required for palynomorph detection in a single slide from often days of manual inspection to under one hour of automated analysis, enabling palynological research at a substantially greater scale.