#01Nov 6, 2026
cs.AI
Can Agentic Systems Close the Gap in Radiology with Production AI Tools?
Aubin Charley, Julien Khlaut, Charles Corbière and 3 more
Radiology AI has developed along two paths: specialized models that perform well on narrow tasks but cover few clinical findings, and generalist models that address a broader range of tasks but remain prone to hallucination and inaccurate measurements. Combining the two through agentic systems offers a route towards comprehensive radiology reporting, but published systems are tied to one modality or body part. We describe a radiology agentic framework that standardizes how an orchestrator calls modular tools to produce a structured report, and use it to measure what such a system can do with the tools from FDA-cleared radiology AI devices. Report generation is simulated on a large multi-modality report corpus, with the orchestrator given either a catalog of finding classes consolidated from the cleared devices, each available on the modalities it is cleared for, or an unlimited catalog in which any class can be requested, and planning either from the clinical indication or from the target report. Tool outputs are simulated from the reference report, so the comparison isolates tool availability and orchestration from tool error. With the cleared catalog and the indication alone, the orchestrator recovers under a third of the clinically actionable findings; recovery improves substantially with the unlimited catalog, and further when the plan is written from the target report. Attributing every missed finding to a cause shows that most are classes no cleared device offers for the study's modality, and that a third are classes or tools that were offered and not called. Adding the most frequently missing tools closes most of the gap to the unlimited catalog on held-out reports, whereas a smaller orchestrator with the unlimited catalog gives up the whole gain. Tool availability and effective orchestration are thus complementary constraints on comprehensive AI-assisted radiology reporting.
#02Nov 6, 2026
cs.AI
Generative Latent Priors for Interpreting and Steering Protein Language Models
Daniel Hinjos, Lucía Urcelay
Dominant methods for interpreting large models impose strong structural assumptions. Generative Latent Priors (GLP) are a complementary approach: a diffusion model that learns the distribution of a frozen model's activations directly, imposing no assumptions. We port GLP to ESM-2 activations (UniRef50) and evaluate it at two host scales (ESM-2-8M and -650M), both as a lens for protein representations and as a prior for editing them. Generation quality scales smoothly with depth and compute. As a lens, single GLP "meta-neurons" are the strongest probes of discrete Swiss-Prot concepts at both hosts, beating InterPLM's released SAE features, and lead on continuous properties at 8M though not at 650M; falsification tests show this is mostly concentration, not new information. As an editing prior, the on-manifold correction makes DiffMean steering of three biochemical properties effective and restores on-manifoldness, but only in isolation: re-embedding the sequences actually produced after several rounds of decoding, the structural plausibility is compromised. This is mainly reproduced in additional SAE-based clamping structural steering experiments, where only Helix motif succeeds. The naturalness failure is traced to the rewriting coverage and the decoder rather than the prior, highlighting what the method must clear before it can serve for both discovery-by-editing and discovery-by-exploration. Trained GLPs are released on huggingface.co/collections/HPAI-BSC/glprot.
#03Nov 6, 2026
cs.LG
Designing Effective Monitor-Based Interventions for Mitigating Reward Hacking During RL
Aria Wong, Joshua Engels, Neel Nanda
Reinforcement learning (RL) rewards are notoriously difficult to design and control, often leading to the model learning unintended behaviors such as reward hacking. One potential solution is to monitor for reward hacking and penalize it when detected; however, training against a monitor could lead to evasive behavior, and our general understanding of how to apply monitors effectively during training is limited. To study how best to use monitors to mitigate reward hacking, we introduce and open source three realistic environments where Qwen3-4B reward hacks: a coding environment hackable via test overwriting, a medical chat environment hackable via sycophancy, and a biography generation environment hackable via hallucination. We first focus on the coding environment, where we find that: (1) models can learn to evade highly accurate monitors by exploiting systemic flaws in probes and LLM judges; (2) monitors that leak more learning signal during RL suppress reward hacking but are more often evaded; and (3) including easier problems in training can decrease reward hacking. We apply our findings to build better reward hacking monitors for the medical chat and biography generation environments that improve upon naive baselines to reduce reward hacking rates across seeds to before-training levels in some interventions. Our results demonstrate that our takeaways translate to new settings and that better monitor intervention designs are possible.
#04Nov 6, 2026
cs.CL
CodeQuant2: Enhanced Outlier Mitigation and Adaptive Clustering for Low-Precision LRMs
Xingyu Liu, Xiangyang Yin, Tianhua Xia and 2 more
Large reasoning models (LRMs) improve task performance by generating longer intermediate reasoning traces, but this substantially increases inference costs and makes low-precision quantization increasingly important. However, aggressively quantized models often perform poorly on reasoning tasks. We observe larger activation fluctuations during the first decoding steps of reasoning. Calibration that omits these early states may miss their activation fluctuations. To address these reasoning-specific quantization challenges, we propose \textbf{CodeQuant2}, a clustering-based LUT quantization framework for low-precision large reasoning models. CodeQuant2 mitigates activation outliers with rotation and scaling, uses clustering to represent non-uniform weight distributions, and adapts codebook sizes to the quantization difficulty of each layer. Guided by our observation of reasoning-time activation behavior, CodeQuant2 further improves calibration sample selection to better match actual decoding statistics. Combined with our customized LUT CUDA kernel, CodeQuant2 delivers substantial accuracy improvements on reasoning benchmarks while achieving up to $2.85\times$ speedup over BF16.
#05Nov 6, 2026
cs.CV
Health-System-Wide Mapping of Demographic Information in Routine Clinical Histopathology
Shengjia Chen, Ruchika Verma, Kevin Clare and 8 more
The extent to which demographic-associated information is detectable across organs and disease states in routine clinical histopathology remains unclear. Here, we analyzed 1.3 million hematoxylin and eosin whole-slide images from 257,322 patients across 25 organs, using pathology foundation-model representations and multiple-instance learning to systematically map information associated with sex, age group, and self-reported race. Across 69 organ-demographic combinations, demographic attributes were broadly recoverable, with pan-organ mean AUROCs of 0.828 for sex, 0.733 for age group, and 0.662 for self-reported race, and substantial variation across organs. Demographic-class balancing produced relatively small changes in performance, while evaluation within diagnosis-text clusters showed modest attenuation. Under training with diagnosis-based grouping, demographic-associated signals remained detectable across multiple organs, including sex in gastric tissue (AUROC 0.865), age group in breast (0.816), and self-reported race in skin (0.728). Literature-guided analysis of these settings generated candidate histomorphological and contextual explanations for further investigation. Together, these findings provide a systematic map of demographic-associated information in routine histopathology, informing investigations of its sources, assessments of potential shortcut learning, and the development of more interpretable computational pathology models.