#01Nov 6, 2026
cs.AI
Generative Latent Priors for Interpreting and Steering Protein Language Models
Daniel Hinjos, Lucía Urcelay
Dominant methods for interpreting large models impose strong structural assumptions. Generative Latent Priors (GLP) are a complementary approach: a diffusion model that learns the distribution of a frozen model's activations directly, imposing no assumptions. We port GLP to ESM-2 activations (UniRef50) and evaluate it at two host scales (ESM-2-8M and -650M), both as a lens for protein representations and as a prior for editing them. Generation quality scales smoothly with depth and compute. As a lens, single GLP "meta-neurons" are the strongest probes of discrete Swiss-Prot concepts at both hosts, beating InterPLM's released SAE features, and lead on continuous properties at 8M though not at 650M; falsification tests show this is mostly concentration, not new information. As an editing prior, the on-manifold correction makes DiffMean steering of three biochemical properties effective and restores on-manifoldness, but only in isolation: re-embedding the sequences actually produced after several rounds of decoding, the structural plausibility is compromised. This is mainly reproduced in additional SAE-based clamping structural steering experiments, where only Helix motif succeeds. The naturalness failure is traced to the rewriting coverage and the decoder rather than the prior, highlighting what the method must clear before it can serve for both discovery-by-editing and discovery-by-exploration. Trained GLPs are released on huggingface.co/collections/HPAI-BSC/glprot.
#02Nov 6, 2026
cs.LG
On the (non-)closedness of the set of ReLU networks
Eloi Martinet, Leon Bungert
We prove that the set $\mathcal{N}_N$ of ReLU networks with one hidden layer and at most $N\in\mathbb N$ neurons is weakly closed in $W^{1,p}(Ω)$, for a bounded connected open set $Ω\subset\mathbb R^d$. Consequently, every coercive, weakly lower semicontinuous energy on this space attains its minimum over $\mathcal{N}_N$. This covers the Deep Ritz method with convex integrands, Sobolev training and Lipschitz learning. Moreover, as the weight decay parameter tends to zero, minimizers of the regularized problem converge, up to subsequences, to minimizers with minimal parameter norm. We also prove that the set of ReLU networks with two hidden layers of bounded widths is not closed in $W^{1,p}(Ω)$ or in $C(\overlineΩ)$. This disproves a conjecture of Petersen, Raslan and Voigtlaender.
#03Nov 6, 2026
quant-ph
Discovering formally verified quantum programs with AI
Sergey Shirobokov, Ben Jaderberg, Katerina Hristova and 22 more
The timeline by which quantum computers can solve breakthrough problems in science depends on improved quantum algorithms as much as on better hardware. Such algorithmic advances are typically achieved through many years of expert human collaboration. In mathematics and computer science, large language models have accelerated progress through automated discovery loops. However, quantum algorithms can only be evaluated by classical computers on restricted or small instances. Here we demonstrate automated discovery of quantum programs beyond these regimes including order-of-magnitude improvements on scientific applications. To achieve this, we build a quantum program library in the Lean theorem prover in which large language model agents synthesize novel programs against formal problem specifications and verify their correctness and cost. Agent teams collaborate, sharing results and knowledge through wikis and discussing ideas at organized conferences. Our results improve on prior baselines for parallel search (up to 1.4x), quantum arithmetic (290x), and simulations relevant to fusion, photochemistry and drug-metabolism by 11x, 8x and 2.5x respectively. Combining human and artificial intelligence at scale, under the rigor of mathematical proof, lets researchers design algorithms that today's classical and quantum computers cannot test, shortening the path to practical quantum computation.
#04Nov 6, 2026
cs.SE
When Instruction Files Go Stale: Documentation Debt and Hidden Cost in Coding Agents
Tural Mehtiyev, Biruk Tadesse, Lawrence Arkoh and 1 more
LLM-based coding agents such as Claude Code are guided by repository instruction files (also called context files or agent configuration files) like AGENTS.md and CLAUDE.md, which are read in every agent session. As any documentation artifact, these files can fall behind the code and become stale (e.g., a test folder moves, but the file still points to the old one). In technical debt terms, such a stale instruction is documentation debt, and its interest is the cost it adds to every later agent session. Evaluations that check only task success can miss this cost, and the stale file can persist. In this study, we ask what leads agents to act on a stale instruction, how it affects their behavior and at what cost, and how they recover. We study three real-world stale instructions from active open-source repositories in depth, each a different kind of guidance: a test command, a code location, and a procedure for adding a component. Agents fix 22 maintenance tasks under three versions of each instruction (left stale, corrected to the current path, and removed), with the code and the task held fixed, and we analyze 732 trajectories of two models at the level of individual tool calls. We find that agents follow stale guidance when it is relevant to their tasks, sometimes even when correct information is available elsewhere. On the stale test command, Claude Sonnet 5.5 needed about two extra tool calls per run, a third more than with the corrected command; in the other cases, we could not detect a difference. Although agents generally recovered from the immediate failures, none repaired the underlying instruction file. Correcting the instructions eliminated operations on obsolete paths, while removing them prevented most. Our findings show that task success alone can hide the costs of documentation debt, highlighting the need to evaluate agent behavior beyond final outcomes.
#05Nov 6, 2026
cs.LG
Computer-Use Agents Are Embodied Generalists
Pranjal Aggarwal, Sean Welleck
In many areas of AI, general-purpose models have increasingly replaced handcrafted methods and specialized architectures. We argue that embodied AI is poised for a similar shift. Our key claim is that embodied tasks can be formulated as interaction with digital software. Specifically, we build software that renders an agent's view of a physical environment on a screen and provides controls for acting in it. A computer-use agent (CUA) can then perform embodied tasks through the same screenshots and keyboard and mouse actions that it uses to operate ordinary software. Using a single CUA design and changing only the software, our entries win first-, second-, third-, and sixth-place prizes across four ECCV workshop competitions, without any competition-specific agent tuning. These results suggest that the skills CUAs learn on software, such as visual grounding, precise clicking, and exploration, already carry over to embodied tasks, giving CUAs a far broader scope in embodied AI than previously realized. We therefore advocate that computer-use agents can be embodied generalists. Further, we advocate that, by following the training strategy that made computer-use agents general, embodied AI can converge on a single general model as well, ushering in a new era of general embodied AI. Website: https://pranjal2041.github.io/cua-embodied