#01Jul 22, 2026
cs.HC
FMRP-LEAN: A HIPAA-Compliant AI-Augmented LIMS Architecture for End-to-End Clinical Assay Workflow Optimization
Eva McCord, Ernest Pedapati, Zag ElSayed
Clinical biomarker workflows in translational research settings often rely on spreadsheet-driven tracking, manual quality control (QC) reconciliation, and loosely integrated systems, resulting in limited state visibility, delayed reporting, and increased operational risk. These challenges are particularly pronounced in multi-day assays such as Luminex-based quantification of Fragile X Messenger Ribonucleoprotein (FMRP), where HIPAA-compliant data governance, deterministic workflow progression, and coordinated communication across laboratory and clinical teams are required. This paper presents FMRP-LEAN, a HIPAA-compliant, AI-augmented Laboratory Information Management System (LIMS) architecture that formalizes biospecimen lifecycle management through a finite-state workflow model with explicit transition guards and dwell-time observability. The system integrates a self-hosted Supabase/PostgreSQL stack deployed within hospital-controlled infrastructure, hybrid edge-internal isolation with encrypted tunneling and loopback-only services, and bi-directional REDCap synchronization. A unified MRN-UUIDv7 identifier framework with QR-based tracking ensures traceable clinical-research linkage under PHI residency constraints. FMRP-LEAN incorporates automated statistical QC pre-screening and a governance-constrained AI operations module that operates exclusively on aggregate projections, with deterministic fallback guarantees. Deployment demonstrates improved workflow observability, reduced QC latency, and enhanced cross-role transparency between laboratory technicians, research coordinators, and patient-facing teams. The architecture provides a reproducible model for secure, state-explicit, and AI-augmented clinical research workflows in regulated healthcare environments.
#02Jul 22, 2026
cs.RO
Closing the Lab-to-Store Gap: A Data-Efficient Post-Training and Experience-Driven Learning VLA Framework for Retail Humanoids
Roger Sala Sisó, Tiago Silvério, Jakob Sand and 1 more
Closing the gap between benchmark performance and reliable real-world operation remains a central challenge for Vision-Language-Action (VLA) humanoid robots, which must handle execution errors, distribution shifts, and environmental variability. This paper presents DEED (Data-Efficient Post-Training and Experience-Driven Learning), a systems-level approach evaluated on a supermarket chip-restocking task using a Unitree G1-Edu humanoid robot and the GR00T N1.6 foundation model. DEED comprises three key components: (1) a data-efficient post-training pipeline with control-frequency alignment, data curation, task-relevant visual highlighting, and reduced VLA dependence; (2) a real-world study of experience-driven refinement, adapted from RECAP via a text-based advantage prefix and a vision-language value function; and (3) a latent-space analysis tool for studying in- and out-of-distribution behavior. Our results suggest that bridging the lab-to-store gap is primarily a systems integration challenge rather than an architectural one: careful data design and targeted post-training can transform a policy that fails under naive fine-tuning into a competent real-world system using only a single GPU.
#03Jul 22, 2026
cs.CL
PyroDash: Cost-Efficient Token-Level Small-Large Language Model Collaborative Inference
Niqi Lyu, Pengtao Shi, Wei Qiu and 4 more
Large language models (LLMs) provide strong reasoning capabilities but are expensive to serve at scale, whereas small language models (SLMs) are cheaper but less reliable on difficult problems. We introduce PyroDash, a cost-aware framework for token-level SLM-LLM collaborative inference. During generation, the SLM decides whether to request assistance by emitting a control token. A Collaborate Engine then sends the query and partial reasoning trace to a frozen LLM for completion through a single handoff. The policy is internalized in the SLM, requiring neither a separate router, LLM retraining, nor access to LLM logits. PyroDash trains the SLM in three stages: control-token embedding learning, offloading-oriented supervised fine-tuning, and cost-aware alignment with Group Relative Policy Optimization. Its reward balances answer accuracy against inference cost normalized by LLM-only inference. Across five mathematical reasoning benchmarks, PyroDash supports different accuracy-cost operating points. With $λ=0.05$, it achieves 64.04 percent average accuracy, 6.36 percentage points above the LLM-only baseline, while reducing cost by 20.4 percent. With $λ=0.6$, it achieves 54.55 percent accuracy with a 1.90 percent LLM token ratio and 0.012 LLM calls per example, reducing total cost from USD 49.36 to USD 1.78. These results show that learned token-level handoffs can reduce LLM use while preserving strong reasoning performance.
#04Jul 22, 2026
cs.LG
Multi-modal transformer for signal classification in nanopore blockade experiments
Sandro Kuppel, Julian Hoßbach, Samuel Tovey and 1 more
Nanopore devices have emerged as powerful tools for single-molecule sensing, with potential for rapid, portable diagnostics. They detect changes in ionic current as analytes enter nanometer-scale pores, providing a means of identifying diverse biomarkers from their characteristic signal patterns. However, these signals are highly complex, and reliably assigning them to specific molecules remains a major challenge. Here, we address this by introducing a multi-modal deep learning architecture that jointly processes multiple signal representations, including raw time-series data, wavelet-based images, and static feature vectors. Our approach surpasses existing methods by more than 10 percentage points on a 42-peptide benchmark and transfers to a 20-amino-acid dataset with near-perfect accuracy. The model integrates complementary information from these representations, with attention analysis showing that the time-series and wavelet-image inputs emphasize different features of the same event. Together, these results demonstrate the potential of machine learning to enable robust, high-accuracy molecular identification with nanopore sensors.
#05Jul 22, 2026
cs.LG
Variance-reduced Domain Adaptation using Paired Sampling
Andrea Napoli
Correlation alignment and the maximum mean discrepancy are two widely used distribution-matching frameworks for unsupervised domain adaptation (UDA). However, high variance in these losses has been shown to undermine their effectiveness in minibatch optimisation settings. Furthermore, the losses lack finite-sum structure, which renders them incompatible with classical stochastic variance reduction (SVR) methods. This paper proposes Paired Sampling for Domain Adaptation (PSDA), a novel SVR technique tailored to such objectives. PSDA pairs observations both within and across domains, to form quadruplets that are always sampled together during training. The pairings are designed to minimise expected gradient variance, and reduce to solving a set of linear assignment problems. Our simulations demonstrate reduced variance compared to related methods, and experiments on three domain shift datasets show improved target domain accuracy.