#01Jul 23, 2026
eess.SP
Toward Generalizable Cognitive Impairment Detection with Speech-Based Multimodal Large Language Models
Yingchao Huang, Xin Wang, Yuhan Su and 1 more
Cognitive impairment (CI) is a growing public health concern. Early and accurate diagnosis is critical for enabling timely intervention and improving patient outcomes. Speech-based CI detection has emerged as a promising non-invasive approach, as speech signals encode both linguistic and acoustic markers associated with cognitive decline. Recent advances in large language models (LLMs) further strengthen the potential of speech-based assessment by enabling more expressive representation learning and improved generalization across diverse speakers, recording devices, and clinical environments. Moreover, multimodal learning by jointly modeling linguistic and acoustic features allows for a more comprehensive characterization of cognitive and behavioral changes related to CI, leading to more reliable detection. In this work, we propose a multimodal CI detection framework based on open-source LLMs that integrates speech audio and corresponding transcripts while preserving patient privacy. Acoustic embeddings are extracted directly from speech signals, while textual embeddings are generated from automatically transcribed speech. These modality-specific embeddings are then concatenated to create a combined feature vector and used for downstream classification, without requiring access to raw or sensitive patient data. The proposed approach is evaluated on the ADReSS20 and ADReSSo21 benchmark datasets. Experimental results show that the proposed multimodal framework achieves an CI classification accuracy of 92.4% and consistently outperforms single-modality baselines. Our work establishes a new state-of-the-art for CI identification, with the proposed method demonstrating superior cross-dataset generalization. This advance highlights the power of an LLM-based multimodal framework that fuses linguistic and acoustic data to enable robust, scalable, and non-invasive screening.
#02Jul 23, 2026
math.ST
Optimal use of a black-box learner in semiparametric estimation
Yihong Gu
Consider the partial linear model $Y = μ_0(X) + β_0 \cdot T + \varepsilon$ and $T = π_0(X) + u$ in the structure-agnostic setting, where we are blind to the structure $μ_0$ and $π_0$ and estimate the nuisances by a black-box hypothesis class. The learnability of the class is characterized by the estimation error $δ_s$ in the absence of model misspecification and its $L_2$ mis-specification error $δ_{a, μ}$ and $δ_{a, π}$ for $μ_0$ and $π_0$, respectively. We propose a novel estimator of the target linear coefficient $θ_0 = β_0$ with error rate \[ \frac{1}{\sqrt{n}} + δ_{a, μ} \cdot δ_{a, π} + [δ_s]^2. \] A matching lower bound is also established, implying that this rate is unimprovable. Compared with the product rate yielded by double machine learning (DML), our estimator removes the suboptimal term $\max(δ_{a, μ}, δ_{a, π})\cdot δ_s$ at no extra cost or assumption. Building on the underlying insights, which are neither tailored to the one-learner setting nor the partial linear model, we propose Transductive Adversarial Moment-calibrated Editing (TAME), which locally edits debiasing weights induced by black-box regression estimates on the inference sample through adversarial conditional moment calibration. TAME can be combined with any initial black-box estimates and can strictly improve on DML guarantees when the nuisance difficulties are imbalanced. We discuss how to fully exploit the advantages introduced by TAME, including the gains from using two learners, the resulting under-smoothing principle for model selection, and extensions to other linear functional estimation problems.
#03Jul 23, 2026
cs.LG
Graph Learning on Ensembles of Cyclic Peptides: An Investigation of Molecular Ensemble Modeling
Aaron Feller, Kris Deibler, Maxim Secor
Molecular property prediction from structure often uses a single representative conformation, even though many molecules exist as conformational ensembles in solution. We introduce EnsembleEGNN, a molecular ensemble foundation model that encodes an ensemble by first encoding each conformer with shared Equivariant Graph Neural Network (EGNN) layers, then pooling the resulting conformer representations with a Set Attention Block. We pretrain the model on CREMP, a cyclic peptide ensemble dataset, using a multi-task self-supervised objective combining masked token recovery, noisy-coordinate reconstruction, and pairwise distance reconstruction. On the CREMP-CycPeptMPDB dataset, training EnsembleEGNN from scratch fails entirely ($R^2=0.005$). However, the pretrained model reaches $R^2=0.477$ and Pearson $r=0.699$, outperforming the sequence-only BERT baseline ($R^2=0.439$, Pearson $r=0.667$). When EnsembleEGNN is co-trained end-to-end with the BERT sequence encoder, the hybrid model improves further to $R^2=0.538$ and Pearson $r=0.737$. These results demonstrate that encoding conformational ensembles into a single thermodynamically informed embedding improves cyclic-peptide property prediction.
#04Jul 23, 2026
cs.CV
ElasticTTT: Prior-Preserving Test-Time Tuning for Video Editing
Yueyi Liu, Chi Zhang, Sen Cui and 1 more
Test-Time Tuning (TTT) on pretrained diffusion models has emerged as a powerful paradigm for video editing. However, there exists a foundational mismatch between the distribution-mapping nature of generative models and the single-point optimization of standard TTT. In this paper, we demonstrate that this mismatch triggers \textit{Prior Collapse}, a degenerate state where the model discards the text conditions and spatial latents, collapsing generations to the source video, or entangling the features of distinct regions. To resolve this, we propose \textbf{ElasticTTT}, a novel framework that preserves the prior generative distribution and rescues generative elasticity. Specifically, we propose \textit{Target Distribution Regularization} to prevent sharp memorization minima, \textit{Contrastive CFG} to guide inference away from source biases, and \textit{Asynchronous Noise Schedule} to preserve unedited regions. Extensive evaluations, supported by theoretical analysis, demonstrate that ElasticTTT successfully preserves the generative prior of the base model, achieving state-of-the-art performance on one-shot video editing.
#05Jul 23, 2026
cs.AI
Toward Continuous Assurance for the Democratization of AI Agent Creation in Industry
Natan Levy, Harel Berger
AI agents are increasingly created inside organizations by non-engineering users through low-code, no-code, and conversational development environments. This democratization enables rapid local innovation, but it also creates a reliability gap: agents that appear to users as simple productivity artifacts may depend on changing models, tools, retrieval sources, permissions, prompts, schedules, and external services. These dependencies can cause silent degradation long after deployment, even when no user directly modifies the agent. This paper identifies the reliability challenge created by democratized AI agent creation and proposes a lightweight continuous-assurance framework for citizen-created organizational agents. The framework combines dependency mapping, readiness contracts, scheduled checks, diagnostics, and lifecycle governance to assess whether an agent remains operationally ready under expected conditions. We also present an initial prototype auditor and scenario-based assessment showing how the proposed taxonomy can be translated into practical checks and actionable remediation guidance.