#01Aug 25, 2026
cs.LG
BioKERN: Biological Kernel Regularization for Histology-to-Transcriptomics Neighborhood Retrieval
Seungik Cho, Betul Orcan-Ekmekci
Spatially resolved biology requires representations that preserve biological neighborhood structure rather than only exact cross-modal correspondences. Existing histology--transcriptomics objectives can emphasize instance-level matching even when non-paired spots share molecular or spatial context. We introduce BioKERN, a multimodal spatial representation-learning framework that incorporates biological structure as an explicit, learnable inductive bias. BioKERN constructs a training-time biological kernel by combining transcriptomic similarity and spatial proximity, then uses it to provide graded neighborhood supervision and regularize embedding geometry. Evaluation uses a fixed, model-independent biological neighborhood definition shared by all methods. Across Mouse Brain Visium and Human Liver GSE240429, BioKERN consistently improves biological-neighborhood retrieval over BLEEP in both single- and multi-scale settings. Controlled shared-architecture experiments show that most of the improvement arises from biological-kernel regularization rather than increased model capacity. These results support explicit biological geometry as an interpretable inductive bias for multimodal learning in spatial biology.
#02Aug 25, 2026
cs.LG
Bellman Calibration for Marginalized Importance Weighting in Offline Reinforcement Learning
Lars van der Laan, Nathan Kallus
Marginalized importance weighting evaluates a target policy by reweighting offline state-action samples with its discounted occupancy ratio, characterized by an adjoint Bellman equation. Existing minimax, primal-dual, and fitted fixed-point estimators can leave residual occupancy-balance violations because of function-class approximation, regularization, or incomplete optimization. These violations are difficult to diagnose and reduce because the objectives generally lack a direct supervised validation loss for hyperparameter tuning, model selection, and early stopping. We introduce isotonic Bellman calibration, a one-dimensional, model-agnostic post-processing method that reduces these violations while preserving the ranking information in any initial occupancy-ratio estimate. The method corrects the estimate's scale and shape by applying fitted occupancy-ratio evaluation (FORE) over a one-dimensional class of nondecreasing transformations. We characterize Bellman calibration as a conditional fixed-point property equivalent to occupancy-balance against every test function of the calibrated ratio. More generally, we derive a calibration-refinement bound showing that any fitted ratio with small calibration error performs nearly as well as the best post-processing based on its fitted values. For isotonic Bellman calibration, we establish finite-sample calibration guarantees and a KL oracle inequality relative to the best monotone transformation of the initial estimate. Consequently, isotonic Bellman calibration achieves small calibration error and KL risk within statistical error of the best monotone correction, with guarantees for downstream target-occupancy functionals, including policy-value estimation.
#03Aug 25, 2026
cs.AI
SPO++: Stream-Aligned Policy Optimization for Asynchronous Agentic RL
Kai Ruan, Jinghao Lin, Qianshan Wei and 2 more
Group-relative reinforcement learning waits for sibling rollouts of the same prompt, which is costly for long and variable tool-use trajectories. Single-stream Policy Optimization (SPO) removes this dependency with a persistent prompt-level value estimate, but its recipe whitens one advantage per trajectory before optimizing a token-mean actor loss. We show that trajectory centering generally does not center the token-weighted quantity consumed by the actor, and fix the mismatch by standardizing terminal-outcome advantages under the action-token measure. We additionally organize prompt evidence by the policy event that generated it rather than learner receipt order. Across matched runs on ALFWorld at two model scales and on Math-TIR, SPO++ improves online learning efficiency over SPO. A paired ablation identifies action-token-measure normalization as the strongest tested component.
#04Aug 25, 2026
stat.ML
What FID Hides: Detecting, Ranking, and Diagnosing Deviations in Generative Evaluation
Hao Chen
Generative models are commonly ranked by Fréchet Inception Distance (FID) and Kernel Inception Distance (KID), yet FID's first-two-moment summary can miss distributional differences, and a reported scalar gap alone is not a calibrated test against sampling variation. FID's moment restriction has concrete consequences: on ImageNet, visually unrecognizable images optimized only to match the reference Inception mean and covariance obtain FID $24.7$ versus $58.6$ for held-out real images (lower is better). Moreover, FID and KID are scalar discrepancies that are unchanged when the two samples are exchanged and therefore do not encode the direction of a dispersion change: under-dispersion, as can occur in mode collapse, versus over-dispersion. We introduce \textbf{ZID} (\emph{Z-resolved Integrated Diagnostic}), which combines six standardized location- and dispersion-sensitive arms from a rank graph (RISE) and Gaussian kernels (GPK at two bandwidths). Rather than asking one scalar to serve incompatible roles, ZID reports three linked outputs: an index for ranking departure magnitude, a permutation $p$-value for testing distributional equality, and a signed dispersion readout for diagnosis. In controlled experiments, ZID detects a broad range of departures, and its score tracks increasing severity along the corresponding sweeps, including cases in which FID is flat or reversed. On DiT-XL/2 and SiT-XL/2 guidance sweeps, ZID detects departure from real data, and its signed readout labels the high-guidance diversity collapse as under-dispersion.
#05Aug 25, 2026
cs.AI
FedV-KGQA: Multi-Hop Question Answering over Vertically Partitioned Knowledge Graphs
Md Saikat Islam Khan Bappy, Oshani Seneviratne
Real-world data for knowledge graph question answering is often distributed across different organizations due to governance and data sovereignty constraints. While centralized systems exist, they cannot answer multi-hop questions when the required facts are split across vertically partitioned silos. In this paper, we propose FedV-KGQA, a framework for multi-hop reasoning over knowledge graphs in which organizations share entities but own disjoint sets of relations. Our approach combines local graph enrichment and knowledge graph embeddings to ensure raw triples and relation parameters never leave each silo, establishing a structural data boundary without requiring centralized graph access. We further introduce a topic entity anchoring mechanism that grounds questions in the correct graph neighborhood without any runtime inter-silo communication. We evaluate 12 model configurations across three benchmarks and show that FedV-KGQA performs strongly, remains close to centralized performance, generalizes to 3-hop reasoning, and is robust to embedding perturbations.