#01Aug 14, 2026
cs.CV
Conditional Neural Optimal Transport for Predicting Cellular Phenotypes from Molecular Structure
Gauthier Avité, Maxime Sanchez-Renauld, Nicolas Bourriez and 1 more
High-content microscopy enables systematic profiling of cellular responses to chemical perturbations, but the scale of the chemical space makes exhaustive phenotypic characterization experimentally infeasible. This motivates computational models that can predict image-derived phenotypes without acquiring the corresponding treated cells. We formulate molecule-induced phenotype prediction as an inductive conditional transport problem in image representation space. Given a negative-control phenotype and the structure of a molecule, we aim to predict the phenotype induced by the corresponding molecule. We first evaluate classical optimal transport baselines and show that static couplings do not yield useful predictions on large-scale phenotypic image datasets. We then introduce a molecule-conditioned Neural Optimal Transport (NOT) model with a Monge-Gap regularization training objective that learns to transport negative-control unperturbed phenotypes toward perturbed phenotypes using molecular structure as conditioning information. NOT recovers molecule-specific phenotypic effects while reducing microscopy-associated technical variation, thereby facilitating comparisons across experimental batches. On unseen active molecules, the model outperforms baseline approaches, demonstrating that chemically conditioned transport can generalize beyond the molecules observed during training. We identified the molecular encoder as the main limitation to this generalization, while transport in a compressed representation space improves performance and scalability. These results establish NOT as a promising framework for predicting cellular phenotypes from molecular structure and negative-control phenotypes, while highlighting the development of more informative molecular representations as a key direction for improving out-of-distribution performance.
#02Aug 14, 2026
cs.CV
On the Robustness of Temporal Vision-Language Models for Surgical Endoscopy Videos
Darakshan Rashid, Raza Imam, Ufaq Khan and 9 more
Temporal vision-language models (TVLMs) offer a reusable, prompt-based interface for surgical video understanding, yet, their robustness under clinically realistic acquisition artifacts in endoscopy remains insufficiently characterized. In practice, degradations such as defocus, haze, motion blur, noise, cautery smoke, and packet loss introduce structured distribution shifts which may compromise video-text alignment. We study the robustness of temporal VLMs under such shifts caused by corruptions in clip frames. We introduce Endo-C6, a compact corruption benchmark of six endoscopy-realistic perturbations evaluated at a fixed high severity, and apply it to public Gastrointestinal (GI) endoscopy and laparoscopic cholecystectomy videos. Under a standardized prompt protocol, we benchmark 3 recent surgical TVLM baselines and analyze robustness in both mean and worst-case settings, spanning 294 dataset-level evaluations. Finally, we present RobustEndoCLIP, obtained by few-shot parameter-efficient tuning with VeRA, outperforming existing TVLM baselines. Our findings show that off-the-shelf TVLMs can exhibit severe worst-case collapse under endoscopy-specific corruptions, whereas lightweight few-shot adaptation can substantially improve corrupted performance and robustness without changing the prompt-based interface. We expect Endo-C6 to support standardized robustness reporting and promote more reliable clinical vision-language systems.
#03Aug 14, 2026
cs.CV
GBU-Palm: A Multimodal Video Dataset and Benchmark for Palm Presentation Attack Detection
Yingjie Ma, Zitong Yu, Wei Jia and 2 more
Existing palm presentation attack detection (PAD) datasets are often limited by static imagery, restricted acquisition conditions, or insufficient multimodal video data, hindering systematic evaluation across environments, modalities, and attack types. We present GBU-Palm, a large-scale multimodal video dataset and benchmark containing 21,326 videos from 105 subjects and 210 palms across six acquisition environments, including bona fide, Print, and Replay presentations, with 6,310 synchronized RGB-NIR samples. We construct leakage-controlled protocols that separate palm identity and attack lineage and benchmark four representative video architectures under environment-matched and held-out-environment settings. Results reveal substantial architecture-dependent degradation under environmental shift and show that RGB-NIR fusion does not consistently outperform RGB-only input. We further analyze model behavior through true accept (TA), true reject (TR), false accept (FA), and false reject (FR) decomposition, spectral masking, temporal-order intervention, and frozen-backbone NIR probing, revealing distinct failure patterns and evidence utilization across architectures. GBU-Palm provides a unified and challenging benchmark for developing and evaluating robust multimodal palm PAD methods under cross-environment conditions.
#04Aug 14, 2026
cs.CV
CPI-Bench: A Comprehensive,Practical and Intelligent Benchmark for Real-World Image Editing
Qinye Zhou, Jun Zheng, Yongchao Du and 17 more
With the rapid advancement of image editing models and their widespread application across various domains, there is an increasingly urgent need to deploy these model capabilities directly into real-world scenarios. However, existing benchmarks remain confined to simple single-image tasks, suffering from limited coverage dimensions and an inability to effectively differentiate performance among diverse models. Consequently, they fail to reliably evaluate model performance in complex multi-image editing, highly demanding reasoning instructions, and practical deployment settings. To address these limitations, we propose CPI-Bench, a Comprehensive, Practical andIntelligent benchmark for real-world image editing. CPI-Bench comprises three core subsets: CPI-General-Bench, which comprehensively covers diverse editing tasks and pioneers the inclusion of multi-image editing evaluation; CPI-Practical-Bench, which focuses on high-frequency real-user application scenarios; and CPI-Intelligent-Bench, which is dedicated to evaluating capabilities in highly demanding reasoning-based editing. Evaluation results of mainstream image editing models based on CPI-Bench demonstrate that CPI-Bench enhances performance differentiation among models. It provides a comprehensive and reliable quantification of gaps in general editing capabilities, practical deployment efficacy, and advanced reasoning-based editing, offering invaluable guidance for the future optimization of image editing models. Crucially, our ranking analysis reveals that CPI-Bench achieves the highest alignment with the Arena Image Edit Leaderboard, indicating it faithfully captures the preferences and perceptual judgments of human evaluators, serving as a robust proxy for real-world user experience.
#05Aug 14, 2026
cs.CV
Seeing Red, Thinking Bad: Color Bias in Vision Language Models
Kohsuke Ide, Ryousuke Yamada, Yoshihiro Fukuhara and 2 more
Vision language models (VLMs) are increasingly used in industrial decision-making systems, such as recruitment support and recommendation. This motivates careful analysis of how VLMs process visual and textual information. In this work, we study how VLMs interpret text rendered as an image, and investigate the influence of visual styling biases. To this end, we introduce Stealth Visual Prompts, which subtly change visual styling of text, such as color and contrast, while preserving semantic content. Using these prompts, we systematically control the visual styling of words in text and measure their impact on the analysis performed by VLMs. We further analyze how such visual perturbations affect the latent representations of the vision encoder. From our experiments, we observed that coloring positive words in green consistently shifts sentiment predictions toward a positive direction. As a result, VLMs often fail to properly account for negative words present in the text. Our analysis suggests that this behavior is correlated with changes in the latent representations of the vision encoder induced by color variations. In addition, we show that reducing text--background contrast increases reliance on visually salient cues and leads to more incorrect Visual Question Answering (VQA) outputs. These results suggest that the visual styling of rendered text can guide VLMs' interpretation in ways that diverge from human semantic understanding. Project page: https://github.com/KohsukeIde/color-bias-vlm