#01Aug 27, 2026
cs.AI
Learning a Continuous Sepsis Severity Score Without Hour-by-Hour Supervision: A Two-Site Retrospective Study
Kevin Zhu, Ryan Zhang, Baraa Abed and 18 more
Currently used sepsis severity indices rely on fixed variables and weights established decades ago, which are coarsely discretized and calibrated to a cohort that no longer reflects contemporary critical care. No alternative learned directly from patient trajectories is in routine use. We conducted a retrospective two-cohort study on a total of 29,116 and 7,691 adult patients meeting Sepsis-3 criteria from two hospital systems in Massachusetts and Georgie, respectively. We developed a sepsis index using 43 routinely charted variables over a 72-hour treatment window. Unlike previous studies, we use mortality as a treatment-level ranking signal rather than a per-state target, allowing credit to be redistributed non-uniformly across timesteps. Evaluation was done on a permanent 20% test holdout, using clinical vignettes and Spearman correlation. Uncertainty intervals were obtained by bootstrap resampling of whole patients. Under this ranking scheme, non-survivors scored 1.19-1.64 points higher than survivors on a 0-10 scale within all strata of baseline SOFA-2, with similar results stratifying within lactate, mean arterial pressure (MAP), and creatinine. Within-patient change in the index correlated with change in lactate (Spearman rho = 0.39; n = 1,854). Similar, weaker correlations were found for MAP and creatinine. On a cohort level, cross-institutional agreement measured by Spearman correlation between models trained on different sites, were 70-77% of same-site correlation. External within-patient correlations were 0.54 and 0.59 against ceilings of 0.92 and 0.90. Our index also correlated with established indices, while null controls stayed near zero. Our index demonstrated hourly prognostic information that meaningfully separates patient outcomes and is consistent with clinical expectation, indicating potential as a decision support tool complementing clinical judgement.
#02Aug 27, 2026
cs.CL
Consolidating RLVR Capabilities Across Domains: A Deep Dive into Fusion Paradigms
Siye Wu, Kai Yang, Yuchen Cai and 8 more
Reinforcement learning with verifiable rewards (RLVR) improves specific capabilities of large language models, but covering multiple capabilities often involves training separate domain experts and subsequently consolidating them. We organize three fusion paradigms by the artefacts they reuse: Merge combines expert task vectors, Mix RL pools their datasets, and multi-teacher on-policy distillation (MOPD) uses both. Because they have largely been studied in isolation, how they compare and how to choose among them remain unclear. We compare all three using shared experts and data across model scales and a multi-domain benchmark suite. Although their average performance differs by at most 1.4 points, the gap reaches 8.6 points on a single benchmark, with domain-level variation tracking cross-domain relations visible in task-vector geometry. Training dynamics expose distinct constraints: Mix RL depends on domain mixture proportions, MOPD remains bounded by its teachers, and Merge compresses all expert updates into one. All three improve single-sample accuracy without measurable gains in solution coverage or losses in held-out capabilities. These results yield a practical guideline: use Merge when experts already exist and cheap fusion is paramount; Mix RL when training a unified model without experts, with domain proportions adjusted for cross-domain transfer; and MOPD when preserving domain-specific gains matters more than surpassing teachers or minimizing end-to-end cost.
#03Aug 27, 2026
cs.CL
Puro-2B: Poor Lab's Qwen2-1.5B Trained on RTX 5090 within $5090
Kairong Luo, Jiarui Cui, Yaorui Yin and 8 more
Language model pretraining has become almost synonymous with prohibitive cost, placing it out of reach for much of the academic and open-source communities. Although strong open-source efforts already exist, including open-weight models and open-source training recipes, a cost-efficient, hardware-accessible, and open-source pretraining recipe has long been missing. Even at a small scale, training Llama-3.2-3B costs over \$1.5M, and reproducing SmolLM3-3B needs over \$700K. In this report, we present an open pretraining recipe designed to lower this barrier. Using this recipe, we train a collection of Puro-2B models from scratch on up to 1.4 trillion tokens with FP8 precision on consumer-grade RTX 5090 GPUs. The models in the collection differ in token budgets and selected recipe variants. Our best model is trained at a compute cost of less than \$6.9K and approaches Qwen2.5-1.5B performance under our evaluation protocol. This cost efficiency is enabled by a combination of approaches, including hardware selection, low-precision training, hyperball optimization, curriculum model averaging, and the data recipe. Beyond the recipe itself, we provide two additional results. First, across the Puro-2B collection, we derive a Puro Cost Scaling Law that relates training cost to average model performance; the fitted law suggests that about \$4.4K, less than \$5,090, is sufficient to reach the performance of Qwen2-1.5B. Second, as an end-to-end case study, we examine how pretraining data curricula shape downstream performance after post-training. Such controlled studies are enabled by having access to the full pretraining pipeline rather than model weights alone. We release the full training recipe for Puro-2B, including data, code, and model weights under Apache 2.0 at https://huggingface.co/collections/thu-pacman/puro-2b.
#04Aug 27, 2026
cs.CL
RATIO: A Benchmark for Retrieval Across Typed Ideation Operations in Scientific Literature
Maayan Sharon, Tom Hope
Retrieved scientific literature can serve as inspiration for both human and AI scientists. Inspiration can take different forms: prior work may directly suggest how to address a problem, or surface directions at different levels of abstraction - zooming out to a more general view or zooming in to a concrete realization. We introduce RATIO (Retrieval Across Typed Ideation Operations), a large-scale benchmark in which relevance is defined by three operations which we name ideation moves: Address retrieves potential approaches for stated problems, Broaden retrieves more general formulations, and Specify retrieves concrete instantiations. RATIO is constructed from millions of full-text scientific papers across CS literature via a general recipe that extends discourse-marker distant supervision - previously used only for classification - to corpus-scale retrieval, combined with extensive LLM and human vetting. Experiments show that operation-specific fine-tuning substantially boosts retrievers but leaves much room for further improvements. RATIO provides a scalable training and evaluation framework for retrieval components that support literature-grounded ideation, opening up new research avenues on scientific inspiration retrieval.
#05Aug 27, 2026
cs.CL
Making Clinical Language Models Auditable: Concept-Guided Fine-Tuning for Robust Prediction
Jin Mu, Guanhua Chen
Clinical language models can achieve strong in-hospital accuracy yet fail under deployment shifts because they exploit note-specific artifacts (e.g., templates, separators, boilerplate) that do not reflect patient state. We propose CAST (Concept-guided Artifact Suppression Tuning), an SAE-based framework for auditable clinical text classification. CAST uses Sparse Autoencoders to expose sparse, human-auditable features from intermediate Transformer activations, labels SAE latents with an LLM-assisted interpretation pipeline and ICD-10 retrieval constraints, suppresses verified artifact latents via residual subtraction during fine-tuning, and provides post-hoc per-concept attributions for auditing model decisions. On MIMIC-IV discharge-note mortality prediction, CAST improves over its corresponding fine-tuned encoder baselines and remains competitive with strong LLM baselines, while producing a feature-level audit trail of the clinical concepts that support each prediction and the artifact concepts suppressed during training.