#01Nov 3, 2026
cs.RO
GUILD: Guided Iterative Data Collection for Imitation Learning
Shivin Dass, Kevin Nguyen, Rohan Yelandur and 2 more
Imitation learning policies in robotics are trained on datasets collected through costly real-world teleoperation. Often, the data-collection process is unguided, relying on the teleoperator's intuition, resulting in data that contributes little to overall policy performance. Recent work has shown that curating such unguided datasets can substantially improve policy performance, but these approaches operate by filtering existing datasets after collection and therefore do not prevent the acquisition of uninformative data. In this work, we propose GUILD, a novel Guided Data Collection (GDC) method that actively reasons about which data should be collected to maximize downstream policy performance. We introduce an iterative framework that alternates between 1) task proposal and data collection and 2) data evaluation to close the loop. For task proposal, we leverage semantic priors from vision-language models to identify relevant environments, object configurations, and goals for data collection. However, since semantic relevance does not imply policy improvement, we perform data evaluation. By leveraging predictive data attribution we approximate how the collected trajectories influence policy performance on a target deployment setting. This signal is then used as feedback to guide subsequent data collection, closing the data collection loop. We evaluate our approach in simulation and real robot settings, demonstrating that guided data collection substantially improves sample efficiency and deployment performance compared to passive data collection strategies, multiple baselines and experienced roboticists. More information at https://robin-lab.cs.utexas.edu/guild2026/
#02Nov 3, 2026
cs.LG
CATF: A Manager-Worker Framework for Context-Aware Time-Series Forecasting
Yueqiao Chen, Dongyu Liu
We study context-aware time-series forecasting, in which a single target variable is predicted from its own history and a set of contextual variables, such as weather and calendar information. As the context becomes more diverse, a single model struggles to capture all of its regimes, while ensemble learning and Mixture-of-Experts approaches rely on manual data partitioning or soft routing, which increases the inference cost and hinders interpretability. We propose CATF, a Context-Aware Time-Series Forecasting framework built on a Manager-Worker architecture: a Transformer-based Manager routes each input to a single Worker based on the context, using hard routing during both training and inference. The Workers thus specialize without manual data partitioning, and any single-model forecaster can serve as a Worker. On five context-rich datasets, four horizons, and two normalization schemes, CATF improves over its standalone counterpart in 162 of 200 comparisons, the best CATF-enhanced model outperforms the best standalone baseline in 19 of 20 settings, and it outperforms the zero-shot Time-MoE foundation model in 15 of 20 settings. A case study on bike-sharing data shows that the Manager routes inputs by the calendar and that each Worker specializes in a different weekly pattern.
#03Nov 3, 2026
cs.LG
iGC: Antibody Optimization via Reinforcement Learning over a Learned Somatic Hypermutation Prior
Thao Nguyen, Robert G. Alberstein, Ewa Nowara and 10 more
Antibody affinity maturation is a natural optimization process in which B cells acquire mutations through somatic hypermutation (SHM), undergo selection for improved antigen binding, and iteratively evolve toward higher affinity. Computationally modeling this process requires capturing both biologically plausible mutations and antigen-specific selection. However, existing mutation models do not directly optimize binding, while affinity optimization often neglects realistic mutation trajectories. We introduce iGC (in silico Germinal Centers), a two-stage reinforcement learning (RL) framework for antigen-specific antibody optimization. Stage 1 learns an SHM mutation prior from parent-child pairs in B-cell lineage trees and adapts it to a target affinity-maturation dataset. Stage 2 initializes an RL policy from this prior and optimizes antigen binding with Kullback-Leibler (KL) regularization toward the frozen prior. To prevent reward exploitation, including repetitive high-reward substitutions and structurally tolerated framework mutations, we introduce a Reward-Tax Meta-Gradient objective. RewardNet smooths the affinity landscape, while TaxNet penalizes reward overexploitation, jointly defining a learned meta-reward for policy optimization. We evaluate iGC on mutation prediction, SHM consistency, affinity optimization, and mutation diversity. The mutation prior more than doubles the strongest baseline in mutation-site prediction. Following RL optimization, iGC maintains SHM sequence structure. It also achieves a strong exploration-exploitation balance, yielding competitive reward-diversity products across candidate-selection cutoffs. These results demonstrate that iGC integrates biologically plausible mutation generation with antigen-specific affinity selection, providing an in silico framework for iterative antibody affinity maturation.
#04Nov 3, 2026
cs.LG
NovoCRF: Globally Normalized De Novo Peptide Sequencing on a Prefix-Mass Lattice
Rui Qiao, Lei Xin, Baozhen Shan
De novo peptide sequencing has moved from dynamic programming over hand-designed or generative scores to large transformers that learn the task end to end. We present NovoCRF, a conditional random field (CRF) whose states are prefix masses, so that its paths are exactly the peptides within +/-0.06 Da of the precursor mass. A small network scores each edge from physics-derived ion-match features and is trained with its scores globally normalized over all mass-feasible peptides. To our knowledge, NovoCRF is the first de novo method trained with exact normalization over all mass-feasible peptides. Our software has three modules, each with exactly one job: a precursor mass finder recovers the accurate precursor mass from MS1, the CRF finds the peptides that fit the precursor mass by exact k-best decoding, and two BiGRU rerankers add sequence context and internal-fragment evidence. The model has 310k parameters and trains in about 17 GPU-hours. On seven held-out data-dependent acquisition datasets published in 2026 (126,262 labeled spectra), NovoCRF's mean peptide recall is 42.4%, against 39.1% for Casanovo v5 with five beams, and its amino-acid recall 64.0% against 53.1%, at 1,746 spectra/s on 18 CPU threads, 55x Casanovo's throughput on a GPU. Split by fragment evidence, NovoCRF leads on labels with up to three peptide bonds without a b or y ion, and Casanovo only beyond. NovoCRF can also search modifications it was never trained on at their exact mass: it finds 32.1% of the hydroxyproline peptides of a lion bone sample.
#05Nov 3, 2026
cs.RO
PolicyIK: High-Precision Inverse Kinematics for Robot Arms with Reinforcement Learning
Yuhan Liu, Xinqi Liu, Zixuan Dong and 2 more
Inverse kinematics (IK) converts end-effector pose commands into joint motion, and many vision-language-action (VLA) policies rely on it to act on a given arm and to transfer across embodiments. Precise IK remains laborious: redundancy and singularities complicate the inverse mapping, execution depends on hand-tuned controllers, and training data on physical robots are costly to collect. We present PolicyIK, a goal-conditioned reinforcement learning policy for high-precision IK. It updates joint-position references from pose feedback and observes its accumulated reference relative to the measured joints, so it can retain the offset that the position controller needs at rest. Two-scale pose errors with an error-dependent action gain resolve millimeter residuals while preserving large motions. Progress and dwell rewards teach it to both reach the tolerance and stay within it. In simulation, a single attempt by the trained PPO policy keeps the mean errors over the final second within 1 mm and 0.2° on 93.5% of held-out tasks, and a deployment protocol raises success to 98.9%. When trained directly on a physical arm with an off-policy RL learner, PolicyIK achieves higher reaching and holding success than all four classical IK controllers under the same time budgets. In simulated pick-and-place, PolicyIK executes the end-effector commands of the $π_{0.5}$ VLA policy with 95.7% success. These results show that reinforcement learning can provide high-precision inverse kinematics for robot arms. Code is available at https://github.com/Tinaliu0123/PolicyIK.