#01Oct 26, 2026
cs.AI
Patient-specific rubric-based evaluation of large language models across longitudinal cancer care
Wei-Wei Zhang, Pengkai Wang, Yan Li and 13 more
Large language models (LLMs) show promise in specialty medicine, yet existing evaluations largely focus on isolated clinical encounters rather than tracking how clinical responsibilities evolve across a longitudinal care pathway. Here we introduce NPC-RubricBench, a phase-aware benchmark for evaluating multistage clinical reasoning across the cancer care continuum, using nasopharyngeal carcinoma as a defined disease context. Curated from longitudinal records of 405 patients across two cancer centers, the benchmark comprises 941 patient-phase units across six sequential care phases and 17,688 patient-specific atomic criteria spanning five evaluation dimensions, with each assessment strictly restricted to decision-time clinical evidence. Evaluating 30 general-purpose and medical LLMs revealed that strong diagnostic performance does not carry over to downstream care. We evaluated 30 general-purpose and medical LLMs, showing that high diagnostic performance did not translate into improved downstream care. Instead, the dominant failure modes reversed across phases. Explicit decision errors dominated anatomical staging at 48.2%, whereas decision omissions dominated initial work-up and post-treatment follow-up at 33.4% and 30.4%, respectively. In the evaluated model set, medically adapted models showed higher omission rates than general-purpose models. Moreover, varying query granularity exposes a critical specification trade-off: broad open-ended requests degrade Decision Quality across all 30 models, while more detailed, checklist-like prompts raise Decision Quality but reduce Evidence Faithfulness and Safety Adherence. Furthermore, NPC-RubricBench demonstrates that static diagnostic benchmarks are insufficient to ensure consistent clinical reliability over time, highlighting the importance of phase-adaptive safeguards in multistage medical AI.
#02Oct 26, 2026
cs.AI
Center-of-Mass Interpretation of Evolution Strategies
Akshat Gupta
Evolution strategies (ES) update a model by sampling a population of perturbed copies, scoring each one, and moving in the reward-weighted direction of the perturbations. This update is usually presented as an estimate of a smoothed gradient. We present a geometrical interpretation of this update instead. Treat each perturbed model as a particle and its reward as the particle's mass. Before scoring, every particle has the same mass and the population balances at its centroid. Once rewards are assigned, it balances at its reward-weighted center of mass instead. We show that the mean-subtracted ES update is exactly this displacement, scaled by a scalar factor that depends on the mean reward, for any finite population. The physical reading needs nonnegative rewards, which can always be arranged by adding a constant to every reward without changing the update. In the limit of a large population or under antithetic sampling, the centroid sits on the model itself, so ES has an even simpler geometric interpretation: from its current location, the model moves towards the reward-weighted center of mass of its own population. The same picture explains what subtracting the mean reward does: it changes the point from which the displacement is measured, from the model to the sampled centroid. Our contribution is an intuitive, geometric way to visualize an ES update, exact for any finite population.
#03Oct 26, 2026
cs.LG
A theory of noisy linear recurrent neural network learning dynamics
John J. Vastola, Kanaka Rajan
Biological neural networks are noisy: their dynamics involve difficult-to-predict fluctuations which are likely due not just to chaos, but also to a variety of low-level biophysical processes. Despite the omnipresence of intrinsic noise, its theoretical consequences are incompletely understood, especially in the context of learning. For example, does noise meaningfully shape representation learning, or is it better viewed as a nuisance factor whose presence or absence changes little about what solution is found and when? Here, we argue that intrinsic noise can significantly modulate representation learning in recurrent neural networks (RNNs), since it can strongly break solution-space degeneracies and in some cases control whether a non-degenerate solution exists at all. We show that this is true for an analytically tractable model of noisy RNN learning with a linear activation function and white noise inputs. We find that, in the so-called rich regime (where weights are initialized with small values), noise strongly modulates the directions in which the read-in, readout, and recurrent weights align. Moreover, we find that noise produces a kind of phase transition: for sufficiently high noise, a non-degenerate solution is not even optimal if parameter scales are limited (e.g., via regularization). These results extend recent analytic work on RNN representation learning and show that noise can act as a fundamental determinant of representations.
#04Oct 26, 2026
cs.CV
VibeVideoBench:Evaluating Multimodal Agents on Code-Driven Video Generation
Muxi Diao, Wenbin Xu, Lele Yang and 21 more
Diffusion video models produce striking clips, but they cannot reliably render an exact formula, a correct chart, a ruleconsistent game or narration synchronized to on-screen events. A different route is emerging: multimodal agents that write code to render every frame and synthesize every sound. We introduce VibeVideoBench, a benchmark for evaluating agents on code-driven video generation. Its 239 self-contained tasks in English and Chinese span 12 categories, from data stories and music-driven pieces to classroom lessons and paper explainers; each asks an agent, running in its native harness inside a sandbox, to deliver a finished MP4 with sound within one hour. Evaluation is hierarchical and evidence-based: program checks of the delivery spec, about 13k task-specific rubric checks traced to the requirements they enforce, and five quality dimensions anchored per task, judged by three VLM judge panels and validated with blind human preferences. Across nine frontier agent systems and 2,151 scored rollouts, the benchmark is far from solved: GPT-6 Astra and Claude Opus 5.5 lead clearly, yet even the best system fails a core requirement on about a quarter of tasks. Whether a video arrives at all matters as much as its quality, and three quarters of the lost videos are final renders started too late, run too slowly or never started. The judges agree with each other and with human preferences on system rankings, but only moderately on individual videos.
#05Oct 26, 2026
q-bio.NC
On the stability of learning
John J. Vastola
Learning algorithms are usually analyzed under the assumption that informative gradients are continuously available. But this is not always true---learning signals in biological neural networks, for example, may be sparse, local, and only intermittently available at any given synapse. In this work, we show that if gradient information is noisy and only intermittently available, learning may be unstable. In particular, even if average learning dynamics converge to the correct optimum, variance in learning may be asymptotically infinite. We explore this point in a number of analytically tractable settings, including single-layer and multi-layer linear networks, and derive explicit conditions under which learning is stable. These conditions complement, but are conceptually distinct from, existing conditions related to the stability of stochastic gradient descent. Our work demonstrates that unbiased credit assignment is not enough for reliable learning; sufficiently frequent and informative feedback is also required, which yields an additional constraint on models of biologically plausible learning.