#01Aug 4, 2026
eess.IV
Unsupervised Adversarial Domain Adaptation for Uterine layer Segmentation: From Labeled Cine to Unlabeled Dynamic EPI MRI
Smiti Tripathy, Milauni Desai, Jordina Aviles Verdera and 1 more
Uterine peristalsis is a key physiological phenomenon responsible for various functions across the menstrual cycle, intimately linked to uterine wall microstructure. Alterations in uterine motion and tissue properties are implicated in the etiology of gynecological diseases, yet these processes have been studied in isolation. We introduce a dynamic multi-echo gradient echo EPI framework for simultaneous characterization and correlation of uterine peristaltic activity and time-resolved T2* changes at 0.55T. Inherent susceptibility artifacts, reduced resolution, and burden of manual uterine layer annotation are addressed by an unsupervised adversarial domain adaptation framework, transferring segmentation knowledge from labeled cine MRI to unlabeled dynamic EPI. We implemented Unet-LSTM with multi-scale domain discriminators that exploits temporal layer dynamics. A Dice score of 0.88 and Jaccard index of 0.80 was achieved. Mean T2* values were 108ms, 76ms, and 124ms for the myometrium, junctional zone, and endometrium. A negative correlation between junctional zone area and T2* was observed in 14/39 cases, providing first insights into oxygenation patterns associated with junctional zone contraction and motion, demonstrating feasibility of assessing the interplay between contractility and dynamic T2* changes.
#02Aug 4, 2026
cs.CV
UniWorld-Design: From Pixel Generation to Layer-Native Design
Zongjian Li, Zhiyuan Yan, Chenxu Bai and 9 more
We introduce UniWorld-Design, a framework that redefines image generation from flat pixel synthesis to structured visual composition, with semantic RGBA layers as the atomic units of generation, understanding, and editing. Our key insight is that pixels define how an image is rendered, whereas layers define how an image is created, understood, and edited. Just as human designers create and manipulate visual content through layers rather than raw pixels, UniWorld-Design equips multimodal generative models with a layer-native design space. UniWorld-Design comprises two models. The Text-to-RGBA (T2RGBA) model generates standalone RGBA assets directly from text. The Image-to-Layer (I2L) model conditions on a finished image, a global instruction and per-layer prompts, and jointly produces ordered, complete semantic RGBA layers. Its instruction interface supports top-level decomposition, recursive decomposition and targeted extraction, making layering an instruction-addressable operation for agentic editing. Because I2L learns complete semantic objects rather than visible-pixel partitions, its layers stay usable when moved or removed. On the Crello benchmark, I2L reduces per-layer RGB L1 error by 37% and achieves a 34% relative improvement in Alpha Soft IoU over Qwen-Image-Layered. Separately, T2RGBA achieves the highest CLIP Score, outperforming LayerDiffuse and OmniAlpha.
#03Aug 4, 2026
cs.CV
Towards Reliable and Reproducible Fetal Brain Biometry: A Deep Learning Approach Using MRI
Francesca Maccarone, Marina Di Stefano, Giorgio Longari and 7 more
Fetal brain biometry is essential for quantitative assessment of brain development, supporting gestational age estimation, developmental monitoring, and detection of abnormalities. In clinical practice, measurements are manually performed, making them time-consuming and prone to variability. While automated approaches have been proposed, reproducible methods remain limited, particularly those providing anatomically interpretable landmark localization. We present a fully automated deep learning-based framework for reliable and reproducible brain biometry from 3D super-resolution-reconstructed fetal brain MRI. The proposed four-step pipeline derives biometric parameters by jointly estimating linear measurements and their corresponding anatomical landmarks. A 3D convolutional neural network is trained to regress landmark coordinates from brain segmentation label maps, followed by measurement-specific geometric optimization to refine landmark positions and compute measurements. The pipeline is evaluated on two publicly available fetal MRI datasets comprising 150 volumes (gestational age range: 20-37 weeks) acquired across different scanners and protocols, assessing five key biometric measurements across varying acquisition settings and providing a comprehensive evaluation of both measurement accuracy and landmark localization using quantitative metrics and visual assessment. Compared with the only available automated pipeline, the proposed method achieves comparable or improved accuracy for most measurements. In conclusion, we introduce a straightforward pipeline for reliable biometry estimations, with efficiency, interpretability and scalability that support integration into clinical workflows.
#04Aug 4, 2026
cs.LG
Latent Reward Registers for Diffusion Preference Alignment
Yuanshen Guan, Zipeng Feng, Zhiwei Xiong and 1 more
Aligning diffusion models with human preferences usually relies on a sparse terminal reward evaluated on the final generated samples, presenting a severe temporal credit-assignment challenge across the multi-step denoising process. We propose Latent Reward Registers, a mechanism that estimates terminal preference directly from intermediate noisy latents by prepending learnable, position-free register tokens to the input sequence of a frozen Diffusion Transformer (DiT). This independent readout mechanism extracts latent reward evidence without altering the generator's hidden states or velocity field. The resulting dense, differentiable reward signal throughout the full denoising process facilitates two alignment strategies. For training, Reward-Gradient On-Policy Distillation (RG-OPD) distills reward-guided updates along on-policy trajectories, bypassing the computationally expensive rollouts of standard policy gradients. For inference, Reward-Guided Sampling (RGS) steers trajectories via magnitude-matched reward gradients without parameter updates. Empirically, at high noise levels (u = 0.8), the registers reach the highest pairwise accuracy among the evaluated latent reward models. Furthermore, RG-OPD outperforms online reinforcement learning baselines while reducing GPU hours by up to 33x, and RGS establishes a new state-of-the-art among training-free methods, strictly enhancing both alignment and perceptual metrics. Code and weights are available at https://github.com/Guanys-dar/latent-reward-register
#05Aug 4, 2026
cs.CV
CARE-X: Towards Clinically Useful Radiology VLMs with Auxiliary Supervision, Reward-Aligned Learning, and Tool-Augmented Measurement
Mercy Prasanna Ranjit, Anirban Porya, Sathvik Joel and 8 more
A clinically useful chest X-ray system must go beyond fluent report generation: it should classify findings with tunable decision thresholds, localize them spatially, and derive the anatomical measurements upon which many diagnoses depend. Today's Vision-Language Models (VLMs) treat these as separate problems, if they address them at all, leaving a gap between what radiologists need and what generative models provide. We introduce CARE-X, a chest X-ray VLM that narrows this gap by unifying auxiliary discriminative supervision with reward-aligned generation. CARE-X augments its generative backbone with focal-loss classification and composite-loss grounding heads, co-trained alongside the language-modeling objective. This auxiliary supervision produces discriminative diagnostic predictions with tunable decision thresholds and precise spatial localization while also improving report quality, providing evidence that structured prediction and generation reinforce one another. Building on this foundation, Decoupled Clip and Dynamic Sampling Policy Optimization (DAPO) leverages task-specific reward signals for report generation, visual question answering (VQA), and spatial grounding, directly optimizing the clinical quality metrics that matter in practice. The result is state-of-the-art performance on the majority of metrics across four report-generation benchmarks, 94.0% VQA accuracy on ReXVQA (+6.0 pp over the next-best baseline), and generative spatial decoding that reaches near parity with dedicated detection heads. Separately, to address measurement-dependent diagnoses, we couple Qwen3-VL-4B-Instruct with native tool-calling capabilities for invoking deterministic measurement tools, while retaining full visual access to the image. This hybrid inference yields +43.6 pp average F1 over perception-only baselines across five measurement-dependent conditions.