#01Nov 12, 2026
cs.CV
A Disease-specific Retinal Aging Biomarker for Predicting Progression to Late Age-related Macular Degeneration
Hexin Dong, Benjamin Hou, Puzhen Wu and 4 more
Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in older adults. While chronological age is a primary risk factor, it inadequately reflects individual variations in retinal aging, limiting effective AMD risk stratification and timely intervention. Here, we propose and validate fundus-based AMD age (FAA), which quantifies disease-specific retinal aging in AMD and captures accelerated AMD-related retinal aging, thereby improving prognostic precision over chronological age. Trained on 36,782 images from 2,192 participants in the Age-Related Eye Disease Study (AREDS) dataset and validated across AREDS and AREDS2 cohorts, our model demonstrates significant improvements over traditional chronological age-based approaches. Specifically, integrating the proposed FAA into Cox proportional-hazards models significantly enhances prediction performance. FAA improved the C-index from 0.836 to 0.888 and reduced the 5-year Brier score from 0.050 to 0.046 in AREDS, with consistent gains observed in AREDS2 (C-index 0.715 to 0.756; 2-year Brier 0.078 to 0.076). FAA showed improved prognostic performance across the two datasets and under different phenotype definitions (reading center-defined vs. specialist-defined grading), supporting its potential utility for AMD risk stratification. These findings highlight the advantage of incorporating FAA into AMD risk prediction frameworks, supporting further evaluation of FAA for AMD risk stratification.
#02Nov 12, 2026
cs.CV
SpotDiff: A Plug-and-Play Framework for Zero-Shot Change Detection in Remote Sensing Imagery
Anit Upadhyaya, Ata Akbari Asanjan, Chaitanya Jalluri and 2 more
Remote sensing change detection usually relies on large collections of temporally aligned, pixel-level annotations, which limits its scalability across regions, imaging platforms and application domains. Recent zero-shot approaches reduce the need for supervision, but they often localize fine-grained changes poorly because their features are coarse or inconsistent across time. We present SpotDiff, a training-free, plug-and-play framework for zero-shot change detection built by composing complementary vision foundation models. SpotDiff uses DINOv3 for semantically robust features, AnyUp to reconstruct them at pixel resolution, and SAM 3 for text-guided region-of-interest proposals, which an inference-time multi-scale strategy (SWIMS) makes reliable on small objects. Change is then measured by comparing the reconstructed features of the two dates inside the proposed regions, with no learnable components, fine-tuning or change labels. To our knowledge, SpotDiff is the first change detection method to use a universal feature upsampler, which alone adds 13.8 F1 over bilinear upsampling of the same features. On LEVIR-CD, SpotDiff reaches 82.46 F1, 2.06 points above the strongest prior training-free method, and on the multi-class SECOND benchmark it improves building change detection by 10.3 IoU and the six-class average by 2.2 IoU. Qualitative results on PlanetScope (3 m) and Sentinel-2 (10 m) imagery show that the same pipeline transfers across resolutions without modification. Our results indicate that composing modern foundation models is an effective route to scalable, label-free change detection.
#03Nov 12, 2026
cs.CV
K2V: Generative Keyframing For Physically Plausible Video Generation
Felix O'Mahony, Daniel Olmeda Reino, Roberto Cipolla and 1 more
Video diffusion models are able to generate samples with high-quality appearance and textural qualities. However, content produced by these methods is known to exhibit significant physical errors. This is because, in a classical video generation setting, all physical reasoning must take place simultaneously and exclusively within the diffusion process.We propose to resolve these issues by redistributing the task of physical reasoning onto a language model-backed keyframe generation module, which allows for explicit reasoning in language, and fine-grained control over the appearance of the video at important moments in the video. We then condition a video generation model with these keyframes, reducing the role of the diffusion model to the simpler task of interpolating between physically-correct intermediate states, rather than inferring an entire sequence with diffusion. Results demonstrate that our approach significantly outperforms existing approaches, achieving state-of-the-art performance on the Physics-IQ Verified benchmark and PhyGenBench.
#04Nov 12, 2026
cs.CV
Predicting Ethanol Drinking Status from Nonhuman Primate Liver Histology: A Proof of Concept for Parameter-efficient Fine-tuning in Few-Shot Vision-Language Modeling
Amirmohammad Mohammadi, Rupak Khadka, Kathleen A. Grant and 2 more
Combining vision-language models (VLMs) with parameter-efficient fine-tuning (PEFT) offers a promising approach to few-shot whole-slide image (WSI) classification in computational pathology. This study evaluates this approach for predicting ethanol drinking status from nonhuman primate liver histology. Adapters are evaluated against non-PEFT configurations on a subset of the Monkey Alcohol Tissue Research Resource (MATRR). All evaluated PEFT configurations achieve higher mean balanced accuracy than the non-PEFT baselines. For example, in the four-shot setting, attention-based multiple instance learning (ABMIL) alone achieves 43.5% mean balanced accuracy, compared with 78.1% after adding an adapter. Qualitative attention analysis shows that textual pathway adaptations produce localized attention heatmaps, while visual pathway adaptations produce more diffuse ones. A pathologist's review identified similar histological features across adaptations.
#05Nov 12, 2026
cs.CV
Objects as Addresses: Instance Binding in Vision Transformer Attention
Khalil Sabri, Guillaume-Alexandre Bilodeau, Nicolas Saunier and 1 more
Humans naturally parse visual scenes into coherent individual objects rather than scattered features, a capability cognitive science calls object binding. While recent work shows that pretrained Vision Transformers (ViTs) intrinsically acquire this ability, how native self-attention computations mechanistically keep object instances separate remains unresolved. By studying this across eight pretrained ViTs, we found that instance separation is expressed more strongly in attention routing than in token content: selected query-key relations distinguish individual objects more reliably than value similarity or residual representations. Inside heads, patches belonging to one individual tend to read from a common image region, which we term their attention address. Visually distinct parts of one person share an address, whereas identical duplicated instances receive separate, movable addresses. These shared destinations arise in part because query interactions with the spatial structure of keys direct attention toward consistent regions for one object and elsewhere for another. In DINOv2 and most other backbones we tested, editing this query component at the selected head redirects its attention address toward another individual. Grouping patches by this query component separates same-category instances, reaching .615 FG-ARI versus .289 for the same clustering of final-layer features, which tend to merge them.