#01Nov 12, 2026
cs.CV
A Disease-specific Retinal Aging Biomarker for Predicting Progression to Late Age-related Macular Degeneration
Hexin Dong, Benjamin Hou, Puzhen Wu and 4 more
Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in older adults. While chronological age is a primary risk factor, it inadequately reflects individual variations in retinal aging, limiting effective AMD risk stratification and timely intervention. Here, we propose and validate fundus-based AMD age (FAA), which quantifies disease-specific retinal aging in AMD and captures accelerated AMD-related retinal aging, thereby improving prognostic precision over chronological age. Trained on 36,782 images from 2,192 participants in the Age-Related Eye Disease Study (AREDS) dataset and validated across AREDS and AREDS2 cohorts, our model demonstrates significant improvements over traditional chronological age-based approaches. Specifically, integrating the proposed FAA into Cox proportional-hazards models significantly enhances prediction performance. FAA improved the C-index from 0.836 to 0.888 and reduced the 5-year Brier score from 0.050 to 0.046 in AREDS, with consistent gains observed in AREDS2 (C-index 0.715 to 0.756; 2-year Brier 0.078 to 0.076). FAA showed improved prognostic performance across the two datasets and under different phenotype definitions (reading center-defined vs. specialist-defined grading), supporting its potential utility for AMD risk stratification. These findings highlight the advantage of incorporating FAA into AMD risk prediction frameworks, supporting further evaluation of FAA for AMD risk stratification.
#02Nov 12, 2026
cs.CV
FLEX-LBP: Learning Local Binary Patterns with Exact Binary Inference for Texture Classification
Mohamed Alimoussa, Amal El Kaid
Local Binary Patterns (LBP) remain among the most widely used texture descriptors, from industrial inspection to medical imaging. Yet their radius, sampling angles, color transform and thresholds are fixed by hand for each dataset. We present FLEX-LBP, which learns these parameters by backpropagation while every forward pass computes exact binary codes and hard histogram counts. A straight-through estimator acts only in the backward pass, so the deployed descriptor is an interpretable hard-binary LBP with 90 learnable parameters and unchanged inference cost. In a controlled ablation on six color texture benchmarks, the component worth learning is dataset-dependent. One configuration, applied unchanged everywhere, learns the geometry and thresholds with the color transform frozen. It improves the nearest-neighbor accuracy of the identical fixed descriptor by 3.55 points on average over five seeds, significantly on five of six benchmarks and never significantly worse. With a linear discriminant readout, it gains 0.9 points; the fully learned descriptor gains 2.7 and has the highest mean. FLEX-LBP is more accurate than five classical LBP-family descriptors, PCANet and a neural LBP on five of six benchmarks. Its mean nearest-neighbor accuracy exceeds that of frozen ImageNet ResNet-50 features (23.5 million parameters). On the Kather colorectal cancer histology benchmark, the fully learned descriptor reaches 93.8%, significantly above the best classical descriptor (Completed LBP, 92.8%). The learned radii adapt in directions that recur across seeds. Noise drowns single-pixel comparisons and illuminant change flips inter-channel ones; median sampling or gray-world normalization restores 96-97%. The code is available as a drop-in PyTorch layer at https://github.com/medalimoussa/FLEX-LBP.
#03Nov 12, 2026
cs.CV
Validation-Guided Prompt Selection for Differential Morphing Attack Detection
Raghavendra Ramachandra, Hailin Li
Differential morphing attack detection (D-MAD) compares a trusted live capture with a document image that may contain a facial morph. We investigate whether labelled validation data can improve a frozen-parameter vision-language evaluator through prompt selection rather than model fine-tuning. Version~1 generates 50 candidate prompts and selects the top-ranked instruction using a security-oriented loss that prioritises missed morph attacks (MACER) while accounting for bona fide classification errors (BSCER), response failures, parse failures, and decision inconsistency. Version~2 recursively revises prompts using aggregate validation feedback. On a subject-disjoint test set of 160 pairs spanning LMA, MIPGAN-2, and PIPE, the selected Version~1 prompt achieves a (19.17\%) morph attack classification error rate (MACER), with (0.00\%) observed bona fide sample classification error rate (BSCER), compared with (70.00\%) MACER for a controlled manual prompt. The paired (50.83) percentage-point difference has a (95\%) subject-bootstrap interval of ([43.33,58.33]). Recursive revision does not surpass the best Generation~0 validation loss; the reported revised descendant obtains (31.67\%) test MACER. All 23 attacks missed by Version~1 are landmark-based (LMA) morphs. Overall, the results show that prompt formulation can substantially influence frozen-parameter VLM-based D-MAD performance, while also highlighting the challenge of recursive prompt refinement under a compact 10-subject validation setting.
#04Nov 12, 2026
physics.flu-dyn
Spatiotemporal learning improves quantification of pore-space evolution and fluid displacement
Zhuangzhuang Ma, Rukuan Chai, Qianqian Ma and 3 more
Pore-space evolution and fluid displacement influence how rocks transmit and store fluids, affecting geological carbon storage, underground hydrogen storage and groundwater contaminant transport. A single time-resolved micro-CT experiment may produce tens to hundreds of three-dimensional images, and segmentation is required to quantify physical properties and run image-based simulations. Traditional methods such as thresholding perform poorly on noisy, low-contrast images and need manual adjustment per image; 3D deep learning networks segment each image without temporal information, so their errors vary between images and could be mistaken for physical change. Here we introduce a transformer-based 4D segmentation framework combining spatial and temporal information. It uses sequential images to resolve ambiguous phase assignments and separate physical change from segmentation error. The method is tested on images of mineral dissolution: it measures pore-volume growth and rock boundaries more accurately than an equivalent 3D model that ignores temporal information. It also captures the increase in permeability verified against reference segmentations and flow simulations. The advantage transfers to another dissolution sample without retraining. On two other datasets of fluid displacement, it reduces spurious changes in predicted rock and porosity fluctuations and accurately identifies filling events. Spatiotemporal segmentation turns sequences of hundreds of three-dimensional images into more reliable quantitative measurements of pore-space evolution and fluid displacement without per-image parameter adjustment to support the analysis of time-resolved CT imaging.
#05Nov 12, 2026
cs.CV
K2V: Generative Keyframing For Physically Plausible Video Generation
Felix O'Mahony, Daniel Olmeda Reino, Roberto Cipolla and 1 more
Video diffusion models are able to generate samples with high-quality appearance and textural qualities. However, content produced by these methods is known to exhibit significant physical errors. This is because, in a classical video generation setting, all physical reasoning must take place simultaneously and exclusively within the diffusion process.We propose to resolve these issues by redistributing the task of physical reasoning onto a language model-backed keyframe generation module, which allows for explicit reasoning in language, and fine-grained control over the appearance of the video at important moments in the video. We then condition a video generation model with these keyframes, reducing the role of the diffusion model to the simpler task of interpolating between physically-correct intermediate states, rather than inferring an entire sequence with diffusion. Results demonstrate that our approach significantly outperforms existing approaches, achieving state-of-the-art performance on the Physics-IQ Verified benchmark and PhyGenBench.