#01Nov 12, 2026
cs.CV
A Disease-specific Retinal Aging Biomarker for Predicting Progression to Late Age-related Macular Degeneration
Hexin Dong, Benjamin Hou, Puzhen Wu and 4 more
Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in older adults. While chronological age is a primary risk factor, it inadequately reflects individual variations in retinal aging, limiting effective AMD risk stratification and timely intervention. Here, we propose and validate fundus-based AMD age (FAA), which quantifies disease-specific retinal aging in AMD and captures accelerated AMD-related retinal aging, thereby improving prognostic precision over chronological age. Trained on 36,782 images from 2,192 participants in the Age-Related Eye Disease Study (AREDS) dataset and validated across AREDS and AREDS2 cohorts, our model demonstrates significant improvements over traditional chronological age-based approaches. Specifically, integrating the proposed FAA into Cox proportional-hazards models significantly enhances prediction performance. FAA improved the C-index from 0.836 to 0.888 and reduced the 5-year Brier score from 0.050 to 0.046 in AREDS, with consistent gains observed in AREDS2 (C-index 0.715 to 0.756; 2-year Brier 0.078 to 0.076). FAA showed improved prognostic performance across the two datasets and under different phenotype definitions (reading center-defined vs. specialist-defined grading), supporting its potential utility for AMD risk stratification. These findings highlight the advantage of incorporating FAA into AMD risk prediction frameworks, supporting further evaluation of FAA for AMD risk stratification.
#02Nov 12, 2026
cs.CV
Back to Pixels: Lifting Latent Video Diffusion into Pixel Space
Yanke Song, Shuo Chen, Chris Rockwell and 9 more
Frontier video generation models work in a VAE latent space that compresses video in both space and time. This compression made training tractable, but now limits high-resolution, controllable, and interactive generation -- doubling resolution quadruples token count, conditions apply to groups of frames rather than individual ones, and each response must wait for the rest of its multi-frame block. We present PixVid, a simple yet effective method that lifts a pretrained latent video model to directly generate every frame in pixel space. PixVid keeps the diffusion transformer and replaces the VAE decoder with a convolutional head that renders its outputs into pixels. We find that predicting clean video rather than velocity, together with a larger noise shift, is key to quality. Finetuned from Wan2.1-14B, PixVid is competitive with the latent baseline within $\sim 1.3$M training clips. Working framewise in pixels, it generates at $2\times$ higher resolution with the same per-frame token count, keeps depth-conditioned video editing aligned under fast motion, and responds to each action at the next frame. Project page: https://chenshuo20.github.io/PixVid/
#03Nov 12, 2026
cs.CV
TuMAP: A Dual-View, Morphotype-Aware Pathomics Pipeline for Quantifying Renal Tubular Remodeling
Ruijie Wu, Yuechen Yang, Yanfan Zhu and 8 more
Quantifying disease-associated renal tubular remodeling is challenging because tubular appearances are heterogeneous. We introduce TuMAP (Tubular Morphotype-Aware Pathomics), a pipeline combining (1) dual-view foundation-model representations and provisional morphotype annotation, (2) compositional and within-morphotype pathomics, and (3) patient-level statistical inference. From 456,158 tubules in 358 PAS-stained kidney biopsy slides, TuMAP identified eight image-based morphotypes, seven of which showed stable subsampling assignments. Across 219 patients in six diagnostic groups, diabetic nephropathy (DN) and tubulointerstitial nephritis/acute tubular injury (TIN/ATI) each differed from minimal change disease in seven morphotype proportions, while IgA nephropathy differed in six. DN showed reduced nuclear solidity and increased eccentricity across all eight morphotypes. Area-normalized nuclear density exposed additional within-morphotype differences. TuMAP provides a framework for separating changes in tubular morphotype composition from phenotypic differences within morphotypes.
#04Nov 12, 2026
cs.CV
Spatial Foundry: A Multimodal Dataset for Spatial Intelligence
Ethan Lin, Yang Song
Spatial intelligence requires connecting visual observations to the geometry, objects, and persistent state of an environment. Images alone leave these relationships implicit, while disconnected annotations make it difficult to study appearance, camera motion, and scene changes under a common reference. We introduce Spatial Foundry, a collection of 5,280 furnished residential 3D scene configurations with editable assets and aligned visual, geometric, and temporal data. Its modalities include floor plans, perspective and panoramic RGB, metric depth, point clouds, meshes, instance-level 3D bounding boxes, and camera trajectories paired with video. Shared scene coordinates link observations across views and time; editable source scenes enable additional camera paths and controlled object changes. We describe the data representation and construction workflow, and discuss applications in floor-plan-conditioned 3D generation, geometric reconstruction, instance-level perception, camera-conditioned video generation, shared world modeling, and scene editing. Controlled camera and scene variations support spatial perception and world-model research. The public project page provides videos and an interactive colored point-cloud preview.
#05Nov 12, 2026
cs.CV
Ropedia Xperience 2: A Gold Standard for Scaling Physical AI Environments and Behaviors
Hao Li, Fangzhou Hong, Zhaoxi Chen and 18 more
Large foundation models such as GPT-6 Astra and Claude Fable 5.1 have recently been shown to control robots directly from visual observations. They nevertheless remain brittle on long-horizon, contact-rich tasks in real-world environments. Further progress depends on two complementary resources: demonstrations of human behavior that supervise how tasks are performed, and interactive environments in which policies can be rolled out, evaluated, and improved in closed loop. Language models have advanced along well-characterized scaling laws; the corresponding question for physical AI is how capability scales with environments and behaviors, which first requires identifying which data to scale and how to produce and reuse such data continuously. To address this question, we introduce Ropedia Xperience 2, comprising 1,589 released metric-scale 3D scans and a collection of 4,230 egocentric recordings of 74 tasks (131 hours). We further show that each capture can be repurposed for robot learning: scenes are converted into physically interactive simulation environments, human motion is retargeted to whole-body robot trajectories, and additional robot behaviors are obtained through virtual teleoperation and automated long-horizon trajectory generation. We propose this joint capture of environments and behaviors as a gold standard for physical AI data collection, laying a data foundation for establishing scaling laws over environments and behaviors.