#01Nov 12, 2026
cs.CV
eDMD: Endpoint Distribution Matching for Few-Step Diffusion Distillation
Tong Zhao, Xianfang Zeng, Yucheng Han and 4 more
Distribution matching distillation (DMD) has emerged as a leading paradigm for distilling diffusion models into few-step students, where an auxiliary fake score model tracks the student's distribution and the discrepancy between the teacher and fake predictions drives the student toward the teacher. In multi-step distillation, although only the student's final output is delivered, existing methods train the fake model on intermediate states or across all denoising steps. Consequently, the student's update signal becomes entangled with intermediate distributions, which can distort the matching direction and remain nonzero even after the student's final outputs already match the teacher distribution. To resolve this mismatch, we propose Endpoint Distribution Matching Distillation (eDMD), which trains a single shared fake model exclusively on the student's final outputs and uses it to correct every denoising step. Our theoretical analysis proves that this endpoint reference guarantees that the distribution matching term vanishes if and only if the student's final output distribution matches the teacher's, regardless of intermediate distributions. Beyond the fake reference, we further strengthen teacher supervision through a precise teacher (PT) that replaces single-step guided predictions with short multi-step trajectories on the final noise interval, paired with a calibrated query density for intermediate steps. Experiments on SD3-Medium, FLUX.2-klein (4B and 9B), and Qwen-Image-2.1 demonstrate that eDMD consistently outperforms existing distribution matching methods for 4-step generation.
#02Nov 12, 2026
cs.CV
TuMAP: A Dual-View, Morphotype-Aware Pathomics Pipeline for Quantifying Renal Tubular Remodeling
Ruijie Wu, Yuechen Yang, Yanfan Zhu and 8 more
Quantifying disease-associated renal tubular remodeling is challenging because tubular appearances are heterogeneous. We introduce TuMAP (Tubular Morphotype-Aware Pathomics), a pipeline combining (1) dual-view foundation-model representations and provisional morphotype annotation, (2) compositional and within-morphotype pathomics, and (3) patient-level statistical inference. From 456,158 tubules in 358 PAS-stained kidney biopsy slides, TuMAP identified eight image-based morphotypes, seven of which showed stable subsampling assignments. Across 219 patients in six diagnostic groups, diabetic nephropathy (DN) and tubulointerstitial nephritis/acute tubular injury (TIN/ATI) each differed from minimal change disease in seven morphotype proportions, while IgA nephropathy differed in six. DN showed reduced nuclear solidity and increased eccentricity across all eight morphotypes. Area-normalized nuclear density exposed additional within-morphotype differences. TuMAP provides a framework for separating changes in tubular morphotype composition from phenotypic differences within morphotypes.
#03Nov 12, 2026
cs.CV
Validation-Guided Prompt Selection for Differential Morphing Attack Detection
Raghavendra Ramachandra, Hailin Li
Differential morphing attack detection (D-MAD) compares a trusted live capture with a document image that may contain a facial morph. We investigate whether labelled validation data can improve a frozen-parameter vision-language evaluator through prompt selection rather than model fine-tuning. Version~1 generates 50 candidate prompts and selects the top-ranked instruction using a security-oriented loss that prioritises missed morph attacks (MACER) while accounting for bona fide classification errors (BSCER), response failures, parse failures, and decision inconsistency. Version~2 recursively revises prompts using aggregate validation feedback. On a subject-disjoint test set of 160 pairs spanning LMA, MIPGAN-2, and PIPE, the selected Version~1 prompt achieves a (19.17\%) morph attack classification error rate (MACER), with (0.00\%) observed bona fide sample classification error rate (BSCER), compared with (70.00\%) MACER for a controlled manual prompt. The paired (50.83) percentage-point difference has a (95\%) subject-bootstrap interval of ([43.33,58.33]). Recursive revision does not surpass the best Generation~0 validation loss; the reported revised descendant obtains (31.67\%) test MACER. All 23 attacks missed by Version~1 are landmark-based (LMA) morphs. Overall, the results show that prompt formulation can substantially influence frozen-parameter VLM-based D-MAD performance, while also highlighting the challenge of recursive prompt refinement under a compact 10-subject validation setting.
#04Nov 12, 2026
cs.CV
Automated PD-L1 Tumor Proportion Scoring with Uncertainty-Guided Triage in Non-Small Cell Lung Cancer
Kesi Xu, Ayesha Azam, Tanvier Kaur and 7 more
Programmed death-ligand 1 (PD-L1) tumor proportion score (TPS) informs immunotherapy selection in non-small cell lung cancer. Near the 1% and 50% cutoffs, the score should also indicate when closer review is warranted. We designed a three-stage framework to follow the sequence of TPS assessment. Stage 1 identifies tumor regions and excludes macrophage-rich patches. Stage 2, a dual-branch cell counting network (D2Count-Net), counts PD-L1-positive and PD-L1-negative tumor cells in these regions to calculate TPS. Stage 3, TPS-Guard, an uncertainty-guided triage mechanism, reports model uncertainty as the disagreement among independently trained models, refers the most uncertain slides, and flags scores near the 1% or 50% cutoff when model estimates disagree across that cutoff. Flags state the reason for referral or alert the pathologist to possible scoring errors on auto-reported slides. In a retrospective, single-center study, 154 whole-slide images were scored by three pathologists, and the model and each pathologist were compared in turn with the mean of the other two. On the 114 slides unseen in training, model mean absolute error (MAE) was 6.96 percentage points, within the range of the three pathologists (4.24 to 8.29), and model uncertainty correlated with absolute TPS error (Spearman rho = 0.77) and inter-pathologist disagreement (rho = 0.71). After referral of the 15% most uncertain slides, model and pathologist MAE both decreased. Applied without retraining to an external, publicly available dataset, TPS-Guard still directed review to higher-error cases, and referring more uncertain cases raised sensitivity at the 50% cutoff. TPS-Guard provides reasons for reviewing individual automated scores and identifies slides that also produce greater disagreement among pathologists. Prospective reader studies should assess TPS-Guard's effect on TPS reporting.
#05Nov 12, 2026
cs.CV
Predicting Ethanol Drinking Status from Nonhuman Primate Liver Histology: A Proof of Concept for Parameter-efficient Fine-tuning in Few-Shot Vision-Language Modeling
Amirmohammad Mohammadi, Rupak Khadka, Kathleen A. Grant and 2 more
Combining vision-language models (VLMs) with parameter-efficient fine-tuning (PEFT) offers a promising approach to few-shot whole-slide image (WSI) classification in computational pathology. This study evaluates this approach for predicting ethanol drinking status from nonhuman primate liver histology. Adapters are evaluated against non-PEFT configurations on a subset of the Monkey Alcohol Tissue Research Resource (MATRR). All evaluated PEFT configurations achieve higher mean balanced accuracy than the non-PEFT baselines. For example, in the four-shot setting, attention-based multiple instance learning (ABMIL) alone achieves 43.5% mean balanced accuracy, compared with 78.1% after adding an adapter. Qualitative attention analysis shows that textual pathway adaptations produce localized attention heatmaps, while visual pathway adaptations produce more diffuse ones. A pathologist's review identified similar histological features across adaptations.