#01Nov 12, 2026
cs.CV
A Disease-specific Retinal Aging Biomarker for Predicting Progression to Late Age-related Macular Degeneration
Hexin Dong, Benjamin Hou, Puzhen Wu and 4 more
Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in older adults. While chronological age is a primary risk factor, it inadequately reflects individual variations in retinal aging, limiting effective AMD risk stratification and timely intervention. Here, we propose and validate fundus-based AMD age (FAA), which quantifies disease-specific retinal aging in AMD and captures accelerated AMD-related retinal aging, thereby improving prognostic precision over chronological age. Trained on 36,782 images from 2,192 participants in the Age-Related Eye Disease Study (AREDS) dataset and validated across AREDS and AREDS2 cohorts, our model demonstrates significant improvements over traditional chronological age-based approaches. Specifically, integrating the proposed FAA into Cox proportional-hazards models significantly enhances prediction performance. FAA improved the C-index from 0.836 to 0.888 and reduced the 5-year Brier score from 0.050 to 0.046 in AREDS, with consistent gains observed in AREDS2 (C-index 0.715 to 0.756; 2-year Brier 0.078 to 0.076). FAA showed improved prognostic performance across the two datasets and under different phenotype definitions (reading center-defined vs. specialist-defined grading), supporting its potential utility for AMD risk stratification. These findings highlight the advantage of incorporating FAA into AMD risk prediction frameworks, supporting further evaluation of FAA for AMD risk stratification.
#02Nov 12, 2026
cs.CV
BrickFlow: Connectivity-Guided Brick Reconstruction
Peter Kulits, Cordelia Schmid
Given a set of LEGO parts and an image of an assembled object, our task is to infer the pose of each part to assemble the object. In contrast with traditional 3D reconstruction, doing so requires satisfying discrete physical constraints, which provide structure but render the problem combinatorial and highly sensitive to small pose errors. To learn a prior over how parts fit together, we train a set-conditioned SE(3) flow model on procedurally generated assemblies. We then finetune this model to inject image conditioning, using 1% as much data. However, while the learned flow captures global structure, it does not enforce connectivity. To address this, we introduce an analytic connectivity-field guidance to pull predictions toward connected assemblies at test time. Through this, we demonstrate improved build quality with model size, pretraining, and guidance. We make our models and data available for research purposes at https://kulits.github.io/BrickFlow/
#03Nov 12, 2026
cs.CV
TuMAP: A Dual-View, Morphotype-Aware Pathomics Pipeline for Quantifying Renal Tubular Remodeling
Ruijie Wu, Yuechen Yang, Yanfan Zhu and 8 more
Quantifying disease-associated renal tubular remodeling is challenging because tubular appearances are heterogeneous. We introduce TuMAP (Tubular Morphotype-Aware Pathomics), a pipeline combining (1) dual-view foundation-model representations and provisional morphotype annotation, (2) compositional and within-morphotype pathomics, and (3) patient-level statistical inference. From 456,158 tubules in 358 PAS-stained kidney biopsy slides, TuMAP identified eight image-based morphotypes, seven of which showed stable subsampling assignments. Across 219 patients in six diagnostic groups, diabetic nephropathy (DN) and tubulointerstitial nephritis/acute tubular injury (TIN/ATI) each differed from minimal change disease in seven morphotype proportions, while IgA nephropathy differed in six. DN showed reduced nuclear solidity and increased eccentricity across all eight morphotypes. Area-normalized nuclear density exposed additional within-morphotype differences. TuMAP provides a framework for separating changes in tubular morphotype composition from phenotypic differences within morphotypes.
#04Nov 12, 2026
cs.RO
UAV-Flow++: A Unified Suite for Benchmarking and Learning Language-Guided UAV Flight
Donglin Yang, Xiangyu Wang, Yantong Zhong and 6 more
Language-guided UAV navigation has largely focused on long-horizon route planning, leaving short-range, object-relative flight maneuvers underexplored. To address this gap, we formulate Flying-on-a-Word (Flow), a task requiring a UAV to convert concise natural-language instruction, egocentric visual observation, and current state dynamics into continuous flight actions. Flow encompasses both primitive motion commands and complex object-interactive behaviors, assessing motion intent comprehension and spatial context grounding. To enable policy learning and closed-loop evaluation, we introduce UAV-Flow, a comprehensive dataset comprising 30,692 expert-piloted real-world trajectories across eight distinct motion categories, alongside 10,109 simulation trajectories in the UAV-Flow-Sim environment equipped with task-specific completion criteria. Furthermore, we develop FlowVLA, which undergoes imitation pretraining on mixed real-sim demonstrations and online post-training via Tail-Aware GRPO (TGRPO). By leveraging group reward distributions, TGRPO effectively reinforces high-reward action sequences. Evaluated on 273 held-out UAV-Flow-Sim episodes, pretrained FlowVLA achieves a mean success rate of 75.58%, outperforming the strongest baseline by 6.72 percentage points, which TGRPO post-training further elevates to 93.16% with superior sample efficiency. Physical UAV experiments demonstrate robust execution of object-relative commands in both indoor and outdoor real-world scenes. Together, Flow establishes a novel benchmark and learning framework for language-conditioned flight maneuvers.
#05Nov 12, 2026
cs.CV
HiVE-VQA: Hierarchical Interaction via Volumetric Embedding for Video Quality Assessment
Robbie Hamilton, Fan Zhang, David Bull
The proliferation of user-generated video content has made accurate and robust no-reference video quality assessment (NR-VQA) a highly important challenge. Existing research increasingly relies on architecturally complex multi-branch pipelines or computationally intensive fine-tuning of single-branch backbones. In this paper, we investigate whether a single frozen video foundation model can serve as an effective NR-VQA backbone, and propose HiVE-VQA, the first framework (to our knowledge) to apply a JEPA-based video encoder to this task. HiVE-VQA extracts token grids from multiple depths of a pre-trained V-JEPA 2.1 encoder and stacks them into a hierarchical spatio-temporal volume, which a compact 3D convolutional head fuses across its layer, spatial, and temporal axes, combining low-level distortion cues from shallow layers with the semantic and temporal context captured at greater depths. The encoder remains frozen throughout, so only the head is trained: 5.2M parameters (5.7\% of the total), with no auxiliary multi-modal models and an inference cost that is invariant to video resolution. Trained solely on LSVQ and evaluated without any fine-tuning, HiVE-VQA outperforms 17 state-of-the-art (SOTA) methods in SROCC and PLCC on both intra-dataset (LSVQ-test, LSVQ-1080p) and cross-dataset (KoNViD-1k, LIVE-VQC) benchmarks. These results indicate that hierarchical, depth-wise fusion of features from a single frozen video foundation model provides a more effective and efficient basis for NR-VQA than task-specific multi-network fusion. Code and model checkpoints are available at https://github.com/RobHam99/HiVE-VQA.